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Sterol Regulatory Element Binding Transcription Factor 2 Proteine (SREBF2)

Bezeichnung:
Sterol Regulatory Element Binding Transcription Factor 2 Proteine (SREBF2)
Auf www.antikoerper-online.de finden Sie aktuell 10 Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Sterol Regulatory Element Binding Transcription Factor 2 Antikörper (87) und Sterol Regulatory Element Binding Transcription Factor 2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 111 Sterol Regulatory Element Binding Transcription Factor 2 Produkte verfügbar.
Synonyme:
AI608257, bHLHd2, lop13, nuc, SREBF2, Srebf2_retired, SREBP-2, SREBP2, SREBP2gc, zgc:158371
alle Proteine anzeigen Gen GeneID UniProt
SREBF2 20788 Q3U1N2
SREBF2 6721 Q12772
SREBF2 300095 Q3T1I5

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Weitere Proteine zu Sterol Regulatory Element Binding Transcription Factor 2 Interaktionspartnern

Mouse (Murine) Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Interaktionspartner

  1. SIRT1 (zeige SIRT1 Proteine) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (zeige AKT1 Proteine) signalling pathway, suggesting that SIRT1 (zeige SIRT1 Proteine) gene may play a protective role against osteoarthritis.

  2. SREBP-2 is critical for survival and limb patterning during development

  3. Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR Proteine) that via p38 MAPK (zeige MAPK14 Proteine) and caspase-3 (zeige CASP3 Proteine) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB Proteine) and pro-NGF (zeige NGFB Proteine).

  4. This study reveals SHP (zeige LAMC1 Proteine) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 Proteine).

  5. activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique

  6. ITCH modulates SIRT6 (zeige SIRT6 Proteine) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (zeige APOE Proteine) null mice

  7. SREBP2-induced miR (zeige MLXIP Proteine)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (zeige SIRT1 Proteine), Kruppel-like factor 2, and Kruppel-like factor 4 (zeige KLF4 Proteine), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (zeige NOS3 Proteine) inhibition.

  8. The cholesterol-lowering effects of FGF21 (zeige FGF21 Proteine) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.

  9. Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.

  10. Demonstrate that the activation of FXR (zeige NR1H4 Proteine) uncouples the expression of nuclear SREBP-2 and miR (zeige MLXIP Proteine)-33, and the regulation of their respective target genes.

Human Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Interaktionspartner

  1. mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR (zeige ELAVL1 Proteine) circuit, although the deficiency triggers transient pro-inflammatory signals.

  2. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.

  3. Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR Proteine) that via p38 MAPK (zeige MAPK14 Proteine) and caspase-3 (zeige CASP3 Proteine) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB Proteine) and pro-NGF (zeige NGFB Proteine).

  4. Data show that mutant p53 protein (zeige TP53 Proteine) activates the sterol regulatory element-binding proteins SREBP-1 (zeige SREBF1 Proteine) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (zeige FLVCR1 Proteine)) cells.

  5. The connections of EGFR (zeige EGFR Proteine) and ERBB4 (zeige ERBB4 Proteine) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (zeige EGFR Proteine)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (zeige EGFR Proteine)-driven cancers.

  6. Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) activated both SREBP-1 (zeige SREBF1 Proteine) and SREBP-2, whereas Akt3 (zeige AKT3 Proteine) upregulated SREBP-1 (zeige SREBF1 Proteine) to enhance hepatitis C virus translation.

  7. knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (zeige Acsl1 Proteine) mRNA and protein levels.

  8. Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (zeige NLRP3 Proteine) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (zeige SREBF1 Proteine)/SREBF2/SCAP (zeige SH2D2A Proteine) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (zeige MBTPS1 Proteine)/S2P (zeige MBTPS2 Proteine).

  9. Data suggest lysophosphatidylcholine (LPC (zeige PCSK7 Proteine)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (zeige PCSK7 Proteine); both LPC (zeige PCSK7 Proteine) and 25-HC up-regulate release of interleukin-6 (zeige IL6 Proteine) and interleukin-8 (zeige IL8 Proteine).

  10. the results of the present study showed that luteolin modulates HMGCR (zeige HMGCR Proteine) transcription by decreasing the expression and nuclear translocation of SREBP-2.

Pig (Porcine) Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Interaktionspartner

  1. dysregulation of SIRT1 (zeige SIRT1 Proteine)-AMPK (zeige PRKAA1 Proteine)-SREBP and stimulation of NLRP3 (zeige NLRP3 Proteine) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis

  2. KLF13 (zeige KLF13 Proteine) and SREBP-Sp1 (zeige SP1 Proteine) activation interact to regulate low density lipoprotein receptor (zeige LDLR Proteine) promoter function

Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) Protein Überblick

Protein Überblick

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Alternative names and synonyms associated with Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2)

  • sterol regulatory element binding transcription factor 2 (SREBF2)
  • sterol regulatory element binding transcription factor 2 (srebf2)
  • sterol regulatory element binding protein 2 (SREBP2)
  • sterol regulatory element binding factor 2 (Srebf2)
  • sterol regulatory element binding protein-2 (SREBP-2)
  • sterol regulatory element binding transcription factor 2 (Srebf2)
  • AI608257 Protein
  • bHLHd2 Protein
  • lop13 Protein
  • nuc Protein
  • SREBF2 Protein
  • Srebf2_retired Protein
  • SREBP-2 Protein
  • SREBP2 Protein
  • SREBP2gc Protein
  • zgc:158371 Protein

Bezeichner auf Proteinebene für SREBF2

sterol regulatory element binding transcription factor 2 , sterol regulatory element-binding protein 2-like , sterol regulatory element binding protein 2 , SREBP-2 , sterol regulatory element-binding protein 2 , sterol regulatory element-binding transcription factor 2 , class D basic helix-loop-helix protein 2 , sterol regulatory element binding factor 2

GENE ID SPEZIES
712307 Macaca mulatta
100070704 Equus caballus
100144677 Xenopus (Silurana) tropicalis
100480211 Ailuropoda melanoleuca
100552463 Anolis carolinensis
100124292 Monodelphis domestica
507102 Bos taurus
100037309 Danio rerio
100502557 Salmo salar
20788 Mus musculus
100008783 Oryctolagus cuniculus
443980 Xenopus laevis
395304 Gallus gallus
6721 Homo sapiens
481228 Canis lupus familiaris
396675 Sus scrofa
300095 Rattus norvegicus
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