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Human F2RL1 ELISA Kit für Sandwich ELISA - ABIN415022
Vasakova, Sterclova, Stranska, Mandakova, Skibova, Matej: Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias. in The open respiratory medicine journal 2013
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findings showed in intestinal epithelial cells that PAR-2 activation leads to polarized IL-8 (zeige IL8 ELISA Kits) secretion in accordance with the side of PAR-2 activation, apical or basolateral, but do not affect ubiquitin proteasome system; demonstrate that PAR-2 activation leads to an increased IL-8 (zeige IL8 ELISA Kits) production and can affect proteasome system, particularly when PAR-2 activation was induced in the apical side
TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (zeige SMAD3 ELISA Kits) that is indispensable for the maintenance of vascular integrity.
PAR-2- and PAR-1 (zeige MARK2 ELISA Kits)-mediated TNF-alpha (zeige TNF ELISA Kits) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.
Results indicate that chymotrypsin-like serine protease (zeige F2 ELISA Kits) enhances soluble fms-like tyrosine kinase 1 (zeige FLT1 ELISA Kits) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody
PAR-2 plays an important role in the progression of ovarian clear cell carcinoma.
Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling, inactivates GSK3b (zeige GSK3b ELISA Kits) signaling, leads to accumulation of beta-catenin (zeige CTNNB1 ELISA Kits), and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (zeige F3 ELISA Kits); PI3K (zeige PIK3CA ELISA Kits) = phosphatidylinositol 3-kinase; AKT (zeige AKT1 ELISA Kits) = proto-oncogene (zeige RAB1A ELISA Kits) protein c (zeige PROC ELISA Kits)-akt (zeige AKT1 ELISA Kits); GSK3b (zeige GSK3b ELISA Kits) = glycogen synthase kinase 3 beta (zeige GSK3b ELISA Kits))
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Studies provide increasing evidence that PAR2 plays a significant role in inflammatory diseases both in the periphery and in the CNS. There is a clear similarity between PAR2 expression and activation on cells of the immune system and those cell types that are proposed to play a role within the CNS, astrocytes and microglia. [review]
Results show that PAR2 in hepatic stellate cells plays a crucial role in promoting hepatocellular carcinoma growth presumably by mediating migration and secretion of pro-angiogenic and pro-mitotic factors.
thrombin (zeige F2 ELISA Kits) has a role in diet-induced obesity through fibrin-driven inflammation
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta (zeige GSK3b ELISA Kits) is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (zeige F10 ELISA Kits) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR2 is critically important in the pathogenesis of adenine-induced tubular injury
The levels of miR (zeige MLXIP ELISA Kits)-223, miR (zeige MLXIP ELISA Kits)-339 and miR (zeige MLXIP ELISA Kits)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (zeige F2 ELISA Kits)-stimulated platelet-derived exosomes in vitro.
Neutrophil elastase (zeige ELANE ELISA Kits) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44/42 MAPK (zeige MAPK1 ELISA Kits) pathway. Blocking neutrophil elastase (zeige ELANE ELISA Kits), PAR2 and p44/42 MAPK (zeige MAPK1 ELISA Kits) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.
Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.
Stimulation of PAR-2 activates Nf-kappaB (zeige NFKB1 ELISA Kits) signaling, resulting in RelA (zeige NFkBP65 ELISA Kits) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.
PAR1 (zeige F2R ELISA Kits) and PAR2 regulate endothelial NO synthase (zeige NOS ELISA Kits) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11