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we clarify the key role of Phe159 and Ile179, two conserved residues within the lid domain, in regulating substrate specificity in MAGL. We conclude by proposing that other structurally related lipases may share this lid-domain-mediated mechanism for substrate specificity.
the presence and differential distribution of fatty acid amide hydrolase (FAAH (zeige FAAH ELISA Kits)) and monoglyceride lipase (MGLL) in relation to CB1 (zeige CNR1 ELISA Kits) during the maturation of human oocytes, was investigated.
there was evidence that MGLL rs604300 genotype interacts with early life adversity to predict threat-related basolateral amygdala habituation, a neural phenotype linked to the endocannabinoid system and addiction
This study unravels a novel mechanism of SND1 (zeige SND1 ELISA Kits) function and identifies MGLL as a unique tumor suppressor for HCC (zeige FAM126A ELISA Kits). MGLL might function as a homeostatic regulator of Akt (zeige AKT1 ELISA Kits) restraining its activation.
Monoacylglycerol lipase sulfenylation might act as an intrinsic neuroprotective mechanism by potentiating 2-AG signaling at CB1 (zeige CNR1 ELISA Kits) receptors.
The study identified monoacylglycerol lipase as a YAP (zeige YAP1 ELISA Kits) transcriptional target and an inhibitor of anchorage-dependent cell growth.
Molecular dynamics and nudged elastic band simulations were used to explore the conformational transition pathway of the helix alpha4 of human monoacylglycerol lipase.
role of monoacylglycerol lipase (MAGL) in the cancer progress
Our findings establish that MAGL promotes metastases in nasopharyngeal carcinoma
In subcutaneous adipose tissue, DAGL-a mRNA was upregulated and fatty acid amide hydrolase (FAAH (zeige FAAH ELISA Kits)) and monoacylglycerol lipase (MAGL) mRNAs were down-regulated in obese subjects, but the diets had no influence.
Results suggest that neuronal and astrocytic MAGL collaborate to terminate endocannabinoid-mediated synaptic suppression and prompt synapse-specificity of endocannabinoid signaling in the cerebellum.
Activities of adipose triglyceride lipase (ATGL (zeige PNPLA2 ELISA Kits)), hormone sensitive lipolitic enzyme (HSL (zeige LIPE ELISA Kits)) and monoacylglycerol lipase (MGL) were significantly higher (51 %, 38 %, 49 %) in the DE group than the HF group (p < 0.05). MGL (zeige CLEC10A ELISA Kits), there were no differences between the CO group, HF group, and DC group, with the DE group (70 %) being significantly higher (p < 0.05).
MGL (zeige CLEC10A ELISA Kits) in astrocytes is an important regulator of 2-arachidonoylglyerol levels, arachidonic acid availability, and neuroinflammation.
Genetic and pharmacological ablation of Magl attenuated centrally-mediated fever response.
the results indicate that global MGL (zeige CLEC10A ELISA Kits) deletion leads to systemic changes that produce a leaner (zeige CACNA1A ELISA Kits) phenotype and an improved serum metabolic profile.
This study showed that Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBR (zeige CBR1 ELISA Kits) signaling and anxiety-like behavior.
Suggest that organophosphate agents induce plasma hypertriglyceridemia in mouse through single or dual inhibition of FAAH (zeige FAAH ELISA Kits) or/and MAGL, apparently leading to overstimulation of cannabinoid signal regulating energy metabolism.
Inactivation of Monoacylglycerol lipase robustly suppressed production and accumulation of beta-amyloid (Abeta (zeige APP ELISA Kits)) associated with reduced expression of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1 (zeige BACE ELISA Kits)) in a mouse model of Alzheimer's disease.
Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo.
The results therefore suggest a role for intestinal MGL (zeige CLEC10A ELISA Kits) in whole body energy balance via regulation of food intake as well as metabolic rate.
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, Monoglyceride lipase
, lysophospholipase homolog
, monoacylglycerol lipase