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anti-Human GIT2 Antikörper:
anti-Rat (Rattus) GIT2 Antikörper:
anti-Mouse (Murine) GIT2 Antikörper:
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Mammalian Monoclonal GIT2 Primary Antibody für ISt, IHC - ABIN1304674
Chadwick, Zhou, Park, Wang, Mitchell, Stone, Becker, Martin, Maudsley: Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. in PLoS ONE 2010
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Human Monoclonal GIT2 Primary Antibody für IF, WB - ABIN393670
Aslan, Baker, Loren, Haley, Itakura, Pang, Greenberg, David, Manser, Chernoff, McCarty: The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. in American journal of physiology. Cell physiology 2013
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.
our work identifies DOCK5 (zeige Dock5 Antikörper) as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 (zeige Dock5 Antikörper) by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac (zeige AKT1 Antikörper) GTPases.
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX (zeige ARHGEF7 Antikörper) complex in health and disease
Short-term EGF (zeige EGF Antikörper) stimulation if of lung tumor cells can increase the interaction between RUSC2 (zeige RUSC2 Antikörper) and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35 (zeige RAB35 Antikörper).
GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
ADMA and L-arginine (zeige GATM Antikörper) are substrates of human CAT2A, CAT2B, OCT2 and MATE1 (zeige SLC47A1 Antikörper). Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine (zeige GATM Antikörper)
Zeb1 (zeige ZEB1 Antikörper) is regulated by the Arf GTPase-activating protein (zeige AGAP4 Antikörper) (GAP) Git2.
GIT2 protein is tightly associated with PIX (zeige ARHGEF7 Antikörper) family Rac1/Cdc42 (zeige CDC42 Antikörper) guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules.
The expression level of lymphocyte GRK (zeige GRK4 Antikörper) might show the severity of CHF, and ACEI treatment could reduce the level of GRK (zeige GRK4 Antikörper) in CHF patients.
GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between
These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration.
GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage
these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.
GIT2 has a key role in regulating the chemokine (zeige CCL1 Antikörper)-mediated motility of double-positive thymocytes
Results suggest that paxillin (zeige PXN Antikörper)-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.
GIT2 links chemotaxis and superoxide production in neutrophils.Loss of GIT2 in vivo leads to an immunodeficient state.
Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.
Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
ARF GTPase-activating protein GIT2
, G protein-coupled receptor kinase-interactor 2
, G protein-coupled receptor kinase interactor 2
, ARF GAP GIT2
, GRK-interacting protein 2
, cool-associated, tyrosine phosphorylated protein 2
, cool-interacting tyrosine-phosphorylated protein 2
, ARF GTPase activating protein 2
, cool associated tyrosine phosphorylated-2
, cationic amino acid transporter-2A
, low affinity cationic amino acid transporter 2
, solute carrier family 7, member 2