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This study presents the atomic model of rabbit TRPV2 in its putative desensitized state, as determined by cryo-EM at a nominal resolution of approximately 4 A.
both TRPV2 and TRPV4 (zeige TRPV4 ELISA Kits) are involved in migration of human cardiac c-kit (zeige KIT ELISA Kits)(+) progenitor cells.
The results of the study show that polymorphism of TRPV2 influenced the susceptibility to FM.
CGRP (zeige S100A12 ELISA Kits)- and TRPV2-containing trigeminal neurons probably innervate the paranasal sinus mucosae, and project into spinal and principal trigeminal sensory nuclei.
transient receptor potential vanilloid 2 is an intracellular Ca(2 (zeige CA2 ELISA Kits)+)-permeable transient receptor potential vanilloid channel upregulated by nerve growth factor via the mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) signaling pathway to augment neurite outgrowth.
Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1 (zeige TRPV1 ELISA Kits), TRPV2, TRPV3 (zeige TRPV3 ELISA Kits) and TRPV4 (zeige TRPV4 ELISA Kits)
There appears to be TRPV1 (zeige TRPV1 ELISA Kits)- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.
This study evaluated the role of Trpv2 in arthritis and the pharmacological effects of Trpv2 agonists.
High expression of TRPV2 mRNA was closely associated with advanced pathological stage and worse survival of patients with esophageal squamous cell carcinoma.
Aim of this review is to study the role of the TRPV2 channel, a member of the TRPV subfamily of TRP (zeige TBPL1 ELISA Kits) channels, in tumor progression. [review]
TRPV1 (zeige TRPV1 ELISA Kits)-, TRPV2-, P2X3 (zeige P2RX3 ELISA Kits)-, and parvalbumin (zeige PVALB ELISA Kits)-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve
data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI
We conclude that TRPV2 function, as a stretch-activated channel, regulates the development of cardiomyocyte hypertrophy in response to increased afterload.
These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12 (zeige TCF3 ELISA Kits)/13 signaling is involved in LPI (zeige Slc7a7 ELISA Kits)-stimulated GLP-1 (zeige GCG ELISA Kits) secretion in enteroendocrine L cells.
Expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway.
TRPV2 channels are demonstrated here to play a key role in cation influx and dysregulation in dystrophin (zeige DMD ELISA Kits) deficient cardiomyocytes, enhanced in stretching conditions
TRPV2KO mice show cold intolerance and impaired BAT (zeige BAAT ELISA Kits) thermogenesis.
We conclude that TRPV2 is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (zeige STK39 ELISA Kits)-activated NKCC1 (zeige SLC12A2 ELISA Kits)
TRPV2-knockout mice have impaired cardiac functional response to exercise.
TRPV2 channels play a predominant role in fluid flow mechanosensitivity over that of TRPC1 (zeige TRPC1 ELISA Kits) and TRP (zeige TYRP1 ELISA Kits) melastatin (zeige TRPM1 ELISA Kits) (TRPM) 7 (zeige TRPM7 ELISA Kits).
TRPV2 is involved in a stretch-activated calcium influx pathway in dystrophic cardiomyopathy, contributing to the defective cellular Ca2 (zeige CA2 ELISA Kits)+ handling in this disease.
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
transient receptor potential cation channel, subfamily V, member 2
, transient receptor potential cation channel subfamily V member 2
, transient receptor potential cation channel subfamily V member 2-like
, osm-9-like TRP channel 2
, vanilloid receptor-like protein 1
, stretch-activated channel 2B
, growth factor regulated channel
, growth factor-regulated calcium channel