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These results indicate that depletion of L8 strongly impairs Drosophila development, and that this depletion is associated with cell proliferation arrest and apoptosis, in which p53 (zeige TUBB Proteine) may play a central role.
Report dysregulated expression of RPL8 in disc degeneration.
confirmed the hydroxylase activity of NO66 (zeige C14orf169 Proteine) and showed that oligomerization is required for NO66 (zeige C14orf169 Proteine) to efficiently catalyze the hydroxylation of Rpl8
gain of RPL8 is associated with good response to chemotherapy in conventional osteosarcomas.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
, ribosomal protein L8
, 60S ribosomal protein L8