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Both CLU (zeige CLU Proteine) and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU (zeige CLU Proteine)-PLXNA4 interactions may have therapeutic value in AD.
Data indicate that plexin A1 (zeige PLXNA1 Proteine)-4 (PLXNA1 (zeige PLXNA1 Proteine)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4.
Rare variants in PLXNA4 and Parkinson's disease.
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) signaling.
These findings suggest that by interacting with PlexA4, TrkA (zeige NTRK1 Proteine) plays a crucial role in redirecting local Sema3A (zeige SEMA3A Proteine) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (zeige GRIA2 Proteine) localization and patterning.
Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A (zeige SEMA3A Proteine) in developing mammalian neurons.
results suggest that Plexin-A4 is involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex.
null mutations in Sema6A (zeige SEMA6A Proteine) or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL (zeige ZIC1 Proteine) stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting.
Findings suggest plexin-A4 and Sema3A (zeige SEMA3A Proteine) as new intervention points for treating sepsis.
suggesting that a Semaphorin6A-Plexin-A4 cis (zeige CISH Proteine) interaction serves as an inhibitory mechanism.
plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1 (zeige PLXNA1 Proteine), plexin-A2 (zeige Plxna2 Proteine) and plexin-A3 (zeige PLXNA3 Proteine))
PlexA4 expressed in oligodendrocyte precursor cells acts as a mediator of semaphorin signals
plexin-A4, as a component of the receptor complex for class III semaphorins, negatively regulates T cell-mediated immune responses
Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.
, plexin A4, A
, plexin A4
, putative plexin 2