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Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting.
Hepatic OSTalpha (zeige OSTALPHA ELISA Kits)-OSTbeta expression is induced by hypoxia.
OSTbeta is a target of RARalpha (zeige RARA ELISA Kits)-mediated (by binding to DR5 (zeige TNFRSF10B ELISA Kits) response element) gene regulation pathways
Ostbeta is required for both proper trafficking of Ostalpha (zeige OSTALPHA ELISA Kits) and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha (zeige OSTALPHA ELISA Kits)-Ostbeta in different tissues.
OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (zeige SULT2A1 ELISA Kits) homeostasis
OSTbeta has roles in biological transport and is widely expressed in human tissues
overexpr (zeige OSTALPHA ELISA Kits)ession of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (zeige NR1H4 ELISA Kits) and the activation of FXR target genes
OSTalpha (zeige OSTALPHA ELISA Kits)/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST (zeige DDOST ELISA Kits) genes by the nuclear bile acid receptor (zeige NR1H4 ELISA Kits)/farnesoid X receptor (FXR (zeige NR1H4 ELISA Kits)).
the selective localization of OSTalpha (zeige OSTALPHA ELISA Kits) and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
Data suggest that transport of bile acid taurocholate is retained when OstB is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA (organic solute transporter alpha subunit (zeige OSTALPHA ELISA Kits)); shorter fragments of OstB are inactive.
Co-expression of mouse Ostalpha (zeige OSTALPHA ELISA Kits)-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha (zeige OSTALPHA ELISA Kits) and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (zeige NR1H4 ELISA Kits)-/-, mice
In conclusion, we identified Ost-alpha (zeige OSTALPHA ELISA Kits)/Ost-beta as a novel FXR (zeige NR1H4 ELISA Kits) target. Absent Ost-alpha (zeige OSTALPHA ELISA Kits)/Ost-beta induction in CA-fed FXR (zeige NR1H4 ELISA Kits)(-/-) animals may contribute to increased liver injury in these animals.
The mouse Ostalpha (zeige OSTALPHA ELISA Kits) and Ostbeta promoters are unusual in that they contain functional FXR (zeige NR1H4 ELISA Kits) and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.
These results indicate that expression of Ostalpha (zeige OSTALPHA ELISA Kits) and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (zeige NR1H4 ELISA Kits).
LXRalpha transcriptionally regulate mouse organic solute transporter alpha/beta via inverted repeat-1 elements shared with farnesoid X receptor
Present as heterodimers (with Ost alpha (zeige OSTALPHA ELISA Kits)) and/or heteromultimers; the interaction between Ostalpha (zeige OSTALPHA ELISA Kits) and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.
These data indicate that Ostalpha (zeige OSTALPHA ELISA Kits)-Ostbeta is essential for intestinal bile acid transport in mice.
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter beta
, organic solute transporter subunit beta
, solute carrier family 51 subunit beta
, organic solute transporter beta subunit
, Ost beta