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enpp1 can exert its function in tissues that are remote from its site of expression.
Results suggest that heterozygous mutations in the SMB domains of ENPP1 are necessary, but not always sufficient in themselves to cause Cole disease.
The K121Q polymorphism of ENPP1 shows no direct correlation with metabolic syndrome in Han Chinese.
Our findings demonstrate that ENPP1, TCF7L2 (zeige TCF7L2 ELISA Kits), and FTO (zeige FTO ELISA Kits) may predispose to T2DM in the mixed-ancestry population.
In this exploratory analysis, IRS1 (zeige IRS1 ELISA Kits), ENNP1 and TRIB3 (zeige TRIB3 ELISA Kits), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (zeige INS ELISA Kits) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
we found that patients with severe asthma exacerbation had reduced activity of leukocyte ectonucleotidases and reduced expression of E-NPP1 in PMNs.
A rare type of idiopathic infantile arterial calcification resulting from a mutation in the gene encoding for the ENPP1 enzyme.
Loss of function mutation in ENPP1 is associated with early onset hearing loss in autosomal recessive hypophosphatemic rickets.
ENPP1 was also identified as a substrate of the 26S proteasome (zeige Psmd4 ELISA Kits), the activity of which is downregulated in CSCs
Expression of NPP1 and 5'-nucleotidase (zeige NT5E ELISA Kits) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (zeige ADORA2A ELISA Kits) and a cAMP/PKA/CREB (zeige CREB1 ELISA Kits) pathway.
ENPP1 rs1805101 polymorphism is associated with Insulin (zeige INS ELISA Kits) resistance and advanced Diabetic nephropathy.
Results show that urine pyrophosphate (PPI) levels are increased in Npt2a (zeige SLC34A1 ELISA Kits)-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj (zeige ARSJ ELISA Kits) alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a (zeige SLC34A1 ELISA Kits)-/- mice.
identified ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) as the first known mammalian enzyme lacking a NUDIX domain to generate pR from ADP-ribose on modified proteins in vitro
Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation.
ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy.
Expression of NPP1 and 5'-nucleotidase (zeige ACPP ELISA Kits) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (zeige ADORA2A ELISA Kits) and a cAMP/PKA/CREB (zeige CREB1 ELISA Kits) pathway.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
NPP1 has a role in obesity and diabetes in a mouse model
we have characterized the phenotypic and histopathologic features of this spontaneous mutant mouse, designated as asj (zeige ARSJ ELISA Kits)-2J, and we have identified a large deletion/insertion mutation in the Enpp1 gene
these data highlight the key role of NPP1 in regulating calcification of both soft and skeletal tissues.
ENPP1 2'3'-cGAMP-hydrolyzing activity is repsonsible for tumor progression in humans and mice.
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
ectonucleotide pyrophosphatase/phosphodiesterase 1
, ectonucleotide pyrophosphatase/phosphodiesterase family member 1
, ectonucleotidase enpp1
, E-NPP 1
, Ly-41 antigen
, alkaline phosphodiesterase 1
, membrane component chromosome 6 surface marker 1
, membrane component, chromosome 6, surface marker 1
, phosphodiesterase I/nucleotide pyrophosphatase 1
, plasma-cell membrane glycoprotein 1
, plasma-cell membrane glycoprotein PC-1
, 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, lymphocyte antigen 41
, phosphodiesterase I/nucleotide pyrophosphatase 1; 1 ectonucleotide pyrophosphatase/phosphodiesterase 1
, tiptoe walking