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Human PFN1 ELISA Kit für Sandwich ELISA - ABIN417949
Chatziharalambous, Lygirou, Latosinska, Stravodimos, Vlahou, Jankowski, Zoidakis: Analytical Performance of ELISA Assays in Urine: One More Bottleneck towards Biomarker Validation and Clinical Implementation. in PLoS ONE 2016
One potential mechanism for C71G-PFN1 to initiate Amyotrophic lateral sclerosis might be the abnormal interaction with membranes as recently established for SOD1 (zeige SOD1 ELISA Kits) mutants.
Expression of PFN1 mutants induces accumulation of TDP-43 (zeige TARDBP ELISA Kits), and promotes conversion of normal TDP-43 (zeige TARDBP ELISA Kits) into an abnormal form. These results provide new insight into the mechanisms of TDP-43 (zeige TARDBP ELISA Kits) proteinopathies and other diseases associated with amyloid-like protein deposition.
We suggest that reduction of PFN-1 expression by elevated levels of PrP(c (zeige PRNP ELISA Kits)) may contribute to protective effects PrP(c (zeige PRNP ELISA Kits))-overexpressing SH-SY5Y cells confer against STS (zeige STS ELISA Kits)-induced apoptosis
this study shows that in pancreatic cancer patients, PFN1 expression is substantially decreased in peripheral CD8 (zeige CD8A ELISA Kits)(+) T cells
mutant profilin1 in various diseases with an emphasis on its contribution to the pathogenesis of amyotrophic lateral sclerosis (Review)
Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.
novel profilin-1 variants associated with amyotrophic lateral sclerosis
We found that ARP3 (zeige ACTR3 ELISA Kits) and profilin1 were 2 binding partners of LMO2 (zeige LMO2 ELISA Kits), primarily in cytoplasm. LMO2 (zeige LMO2 ELISA Kits). LMO2 (zeige LMO2 ELISA Kits) mediated the assembly of a complex including ARP3 (zeige ACTR3 ELISA Kits), profilin1, and actin monomer, increased actin monomer binding to profilin1, and promoted lamellipodia/filopodia formation in basal-type breast cancer cells.
These observations indicate that our novel profilin1 mutant mouse line may provide a new ALS model with the opportunity to gain unique perspectives into mechanisms of neurodegeneration that contribute to ALS pathogenesis.
These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 mutations exacerbate TDP-43 (zeige TARDBP ELISA Kits)-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 (zeige TARDBP ELISA Kits) from nuclei to cytoplasm.
Profilin1 is expressed in osteocytes and regulates cell shape, migration and bone mass.
overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response
Pfn1 is a novel target of BMP and suppresses BMP-induced differentiation of osteoblasts at least in part via transcriptional event.
knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation.
Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Depleting FMNL1 (zeige FMNL1 ELISA Kits), another Formin (zeige FMN1 ELISA Kits) family member, resulted in reduced mDia1 expression, while RhoA (zeige RHOA ELISA Kits) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (zeige FMNL1 ELISA Kits)-mDia1-Profilin1 signaling pathway in mouse oocytes.
association of cortactin (zeige CTTN ELISA Kits) with Pfn-1 is regulated by c-Abl (zeige ABL1 ELISA Kits)-mediated cortactin (zeige CTTN ELISA Kits) phosphorylation
In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha (zeige HIF1A ELISA Kits) expression leading to vascular abnormalities and tumor progression.
Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation.
biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin
nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline).
Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos.
Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers.
PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.
formed a filamentous network likely associated with actin filaments
protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo
Thus the model organism Caenorhabditis elegans expresses three profilin isoforms and is the first invertebrate animal with tissue-specific profilin expression.
profilin promotes actin organisation
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.
, profilin 1
, epididymis tissue protein Li 184a
, profilin I
, actin binding protein