HIV-1 gp41
Spezies: Human Immunodeficiency Virus (HIV)
Recombinant
Applikationshinweise
ELISA: 1:500-1:1,000, WB: 1:500-1:1,000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Reconstitute in sterile distilled water.
Buffer
Supplied lyophilized from PBS buffer, with no preservatives added,
Konservierungsmittel
Without preservative
Handhabung
Avoid repeated freeze/thaw cycles.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -70 °C for long term storage.
Du, Idiart, Mariano, Chen, Jiang, Xu, Ostrow, Wrin, Phung, Binley, Petropoulos, Ballantyne, Whalen: "Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein." in: Virology, Vol. 395, Issue 1, pp. 33-44, (2009) (PubMed).
Opalka, Pessi, Bianchi, Ciliberto, Schleif, McElhaugh, Danzeisen, Geleziunas, Miller, Eckert, Bramhill, Joyce, Cook, Magilton, Shiver, Emini, Esser: "Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay." in: Journal of immunological methods, Vol. 287, Issue 1-2, pp. 49-65, (2004) (PubMed).
Target
HIV-1 Transmembrane Glycoprotein (HIV-1 gp41)
Andere Bezeichnung
HIV1 gp41
Substanzklasse
Viral Protein
Hintergrund
GP41 is a glycoprotein subunit that remains non-covalently-bound to gp120, and provides the second step by which HIV enters the cell. It is originally buried within the viral envelope, but, when gp120 binds to a CD4, gp120 changes its conformation, causing gp41 to become exposed, where it can assist in fusion with the host cell. Alternative Names: gp41 antigen, HIV 1 gp41, HIV-1 gp41 protein, gp41 antigen, gp41 glycoprotein antigen, Glycoprotein 41 antigen, Envelope surface glycoprotein gp41 antigen, HIV-1 gp41 antigen, Human Immunodeficiency Virus 1 antigen, HIV1 gp41, Surface protein antigen, SU antigen, HIV 1 gp41 protein, HIV-1 gp41, HIV 1 gp41 antigen