CITED2
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, SDS, WB
CITED2 is an important transcriptional cofactor involved in multiple organ development. It is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300. CITED2 is necessary for mouse fetal liver hematopoiesis and is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Recombinant CITED2 protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Cbp/p300-interacting transactivator 2, MRG1, P35SRJ, CITED2, Cbp/p300-interacting transactivator 2 Cbp/p300 interacting transactivator 2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2, MRG 1, MSG related protein 1,. NCBI no.: NP_006070