IL16 Protein (AA 10-130)
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- Target Alle IL16 Proteine anzeigen
- IL16 (Interleukin 16 (IL16))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 10-130
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Applikation
- Flow Cytometry (FACS)
- Reinheit
- >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- Endotoxin-Niveau
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Less than 0.1 ng per μg of protein.
- Top Product
- Discover our top product IL16 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Biological activity: Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0 - 1000.0 ng/ml.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- Buffer
- Lyophilized, carrier-free.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Unopened vial can be stored at -20°C or -70°C.
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- Target
- IL16 (Interleukin 16 (IL16))
- Andere Bezeichnung
- IL-16 (IL16 Produkte)
- Synonyme
- IL16 Protein, LCF Protein, NIL16 Protein, PRIL16 Protein, prIL-16 Protein, mKIAA4048 Protein, IL-16 Protein, interleukin 16 Protein, IL16 Protein, Il16 Protein
- Hintergrund
- IL-16 is a proinflammatory cytokine synthesized as a 631-amino acid precursor protein (pro-IL-16). The pro-IL-16 is expressed at high level in T cells. After cell activation via the T cell rceptor, the C-terminal cytokine domain (121 amino acids) can be released from the N-terminal prodomain by caspase-3 and become biological active. Self-aggregation into homotetramer is required for its biological activities. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. IL-16 also induces the expression of CD25 and activates CD4+ T cells synergically with IL-2 or IL-15. IL-16 can also induce IL-1, IL-6 and TNF-α production in monocytes. It has been shown tha IL-16 can inhibit HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. The pro-IL-16 has been identified as a T lymphocyte cell cycle growth suppressor. In primary T cells, nuclear presence of pro-IL-16 results in a resting state. Pro-IL-16 can function as a scadffold protein which can interact with GA-binding protein β, HDAC3, and heat shock protein 70.
- Molekulargewicht
- The 121 amino acid recombinant protein has a predicted molecular mass of approximately 12.4 kDa. The predicted N-terminal amino acid is Ser.
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