IL29 Protein (AA 20-200) (His tag)

Produktnummer ABIN2181309

Produktdetails

Target: IL29 (Interleukin 29 (IL29))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-200

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL29 Protein ist gelabelt mit His tag.

Sequenz: AA 20-200

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Antigendetails

Target: IL29 (Interleukin 29 (IL29))

Andere Bezeichnung: IL-29 (IL29 Produkte)

Synonyme: IL-29 Protein, IL29 Protein, interferon lambda 1 Protein, interferon lambda-1 Protein, interleukin 29 (interferon, lambda 1) Protein, IFNL1 Protein, LOC612539 Protein, IL29 Protein

Hintergrund: Interleukin-29, is a secreted protein which belongs to the IL-28 / IL-29 family, and is a type III interferon. It is also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, IFNλ1, IL-29 and IFNL1, and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL28A, IL28B, and IL29, also named interferonλ2 (IFNλ2), IFNλ3, and IFNλ1, respectively, are classII cytokine receptor ligands that are distantly related to members of the IL 10 family (11-13 % aa sequence identity) and the type I IFN family (15-19 % aa sequence identity). Human IL29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67 % and 69 % aa sequence identity with human IL28A and IL28B, respectively. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses and also may play a role in antiviral immunity. Interleukin-29 / IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Molekulargewicht: 21.1 kDa

NCBI Accession: NP_742152