Signal Transducing Adaptor Family Member 1 (STAP1) protein (His tag)

Details zu Produkt Nr. ABIN1098624, Anbieter: Anmelden zum Anzeigen
Proteinname
  • BRDG1
  • STAP-1
  • AI586015
  • Brdg1
  • RGD1311584
  • Stap-1
  • signal transducing adaptor family member 1
  • BCR downstream signaling 1
  • STAP1
  • BRDG1
  • LOC100356823
  • Stap1
Spezies
Human
5
3
1
Quelle
Escherichia coli (E. coli)
6
2
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
His tag
Applikation
SDS-PAGE (SDS)
Optionen
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Reinigung purified by using conventional chromatography.
Reinheit > 95 % by SDS - PAGE
Hintergrund STAP1, also known as signal-transducing adaptor protein 1, appears to functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. Recombinant human STAP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Molekulargewicht 36.8 kDa (319aa), confirmed by MALDI-TOF
NCBI Accession NP_036240
Forschungsgebiet Signaling
Kommentare

Synonyms: Signal-transducing adaptor protein 1, BRDG1, STAP-1

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/ml (determined by Bradford assay)
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.1 M NaCl, 1 MM DTT
Lagerung 4 °C
Informationen zur Lagerung Avoid repeated freezing and thawing cycles.
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 image for Signal Transducing Adaptor Family Member 1 (STAP1) protein (His tag) (ABIN1098624) Signal Transducing Adaptor Family Member 1 (STAP1) protein (His tag)
Allgemeine Veröffentlichungen Beausoleil, Villén, Gerber, Rush, Gygi: "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." in: Nature biotechnology, Vol. 24, Issue 10, pp. 1285-92, 2006 (PubMed).

Ohya, Kajigaya, Kitanaka, Yoshida, Miyazato, Yamashita, Yamanaka, Ikeda, Shimada, Ozawa, Mano: "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 21, pp. 11976-81, 1999 (PubMed).