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Rat (Rattus) GLP1R ELISA Kit für Sandwich ELISA - ABIN433711
Chen, Xu, Xiao, Zhou, Zhang, Lin, Gong: Blockade of Central GLP-1 Receptors Deteriorates the Improvement of Diabetes after Ileal Transposition. in International journal of medical sciences 2016
Mouse (Murine) GLP1R ELISA Kit für Sandwich ELISA - ABIN426626
Qi, Chen, Wang, Liu, Liu, Ke, Zheng, Lin, Zhou, Wu, Liu: Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β. in American journal of translational research 2017
Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
cryo-electron microscopy structure of the peptide-activated GLP-1R-Gs complex at near atomic resolution
crystal structure of the full-length GLP-1 receptor bound to a truncated peptide agonist
crystal structures of the human GLP-1R transmembrane domain in complex with two different negative allosteric modulators, PF-06372222 and NNC0640, at 2.7 and 3.0 A resolution, respectively
Data suggest that pancreatic level of GLP1R is highest in insulin (zeige INS ELISA Kits)-secreting cells; here, highest intensity of GLP1R immunostaining was observed in beta-cells in pancreatic tissues obtained from organ-donor cadavers with type 2 diabetes.
Data show that purified glucagon-like peptide-1 (GLP-1 (zeige GCG ELISA Kits)) receptor (GLP1R)GLP1R in nanodiscs that could bind to GLP-1 (zeige GCG ELISA Kits) and exendin-4 and activate Gs protein.
Dapagliflozin, when added in real life to patients with T2DM treated with GLP1-R agonists, induced a further significant, albeit modest improvement in A1C and a further weight loss.
analysis of the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor
GLP1-R may represent a novel target for treating bronchial hyperresponsiveness.
Our studies show that GLP-1R is widely expressed throughout the human hypothalamus. The decreased expression of GLP-1R in the PVN and IFN of T2DM patients may be related to the dysregulation of feeding behavior and glucose homeostasis in type 2 diabetes mellitus.
The effects of GLP-1 (zeige GCG ELISA Kits)-based therapies on blood glucose in type 2 diabetics are not mediated through microvascular responses.
In conclusion, exenatide significantly improves coronary endothelial function in patients with newly diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK (zeige PRKAA1 ELISA Kits)/PI3K (zeige PIK3CA ELISA Kits)-Akt (zeige AKT1 ELISA Kits)/eNOS (zeige NOS3 ELISA Kits) pathway via a GLP-1R/cAMP-dependent mechanism.
Study showe that GLP (zeige GOLGA6A ELISA Kits)-producing fibers interact with hypothalamic arcuate nucleus (ARC (zeige NOL3 ELISA Kits)) Kiss1 (zeige KISS1 ELISA Kits) cells that express GLP-1R, and GLP-1R signaling directly activates ARC (zeige NOL3 ELISA Kits) Kiss1 (zeige KISS1 ELISA Kits) function in an estradiol-independent manner. Pharmacological activation of GLP-1R signaling during fasting or pharmacological inhibition of CNS GLP-1R signaling during normal feeding does not alter circulating luteinizing hormone levels.
The increased calcium response mediated by secretin (zeige SECR ELISA Kits) in the absence of GLP-1R was paralleled by an increased glucose-dependent insulin (zeige INS ELISA Kits) response, indicating that the heterodimeric receptor complexes modulate secretin (zeige SECR ELISA Kits) responses.
Menin and PRMT5 (zeige PRMT5 ELISA Kits) suppress GLP1R transcript levels and PKA-mediated phosphorylation of FOXO1 (zeige FOXO1 ELISA Kits) and CREB (zeige CREB1 ELISA Kits).
Glp1r knockdown reduced anxiety-like behavior, implicating paraventricular nucleus GLP-1 (zeige GCG ELISA Kits) signaling in behavioral stress reactivity
Enhanced beta-cell GLP-1R signaling contributes to improved glucose regulation after vertical sleeve gastrectomy by promoting increased glucose-stimulated insulin (zeige INS ELISA Kits) secretion.
Results suggest a detectable but only modest role for GLP-1R signaling in mediating the effects of Roux-en-Y gastric bypass and that this role is limited to its well-described action on glucose regulation.
Hypothalamic Glp1r is sufficient but not necessary for regulation of energy balance and glucose homeostasis.
Genetic deletion of both GLP-1 (zeige GCG ELISA Kits) and GIP (zeige GIP ELISA Kits) receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose.
present study provides critical insights regarding the nature by which GLP-1 (zeige GCG ELISA Kits) signaling controls reinforced behaviors and underscores the importance of both peripheral and central GLP-1R signaling for the regulation of addictive disorders.
CB1 (zeige CNR1 ELISA Kits) activation negatively impacts GLP-1R-mediated insulin (zeige INS ELISA Kits) secretion.
induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure
glucagon-like peptide 1 receptor
, glucagon-like peptide 1 receptor-like
, GLP-1 receptor
, pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1