Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human Hexokinase 2 Antikörper:
anti-Mouse (Murine) Hexokinase 2 Antikörper:
anti-Rat (Rattus) Hexokinase 2 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal Hexokinase 2 Primary Antibody für WB - ABIN1882090
Kuwabara, Ishikawa, Kobayashi, Kobayashi, Sugiyama: Renal clearance of a recombinant granulocyte colony-stimulating factor, nartograstim, in rats. in Pharmaceutical research 1996
Show all 5 Pubmed References
Human Monoclonal Hexokinase 2 Primary Antibody für FACS, IHC - ABIN969196
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
Show all 3 Pubmed References
Mouse (Murine) Polyclonal Hexokinase 2 Primary Antibody für IHC, WB - ABIN3021256
Guo, Yao, Zhan, Hu, Yue, Cheng, Liu, Ye, Qing, Zhang, Liu: N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. in Toxicology and applied pharmacology 2014
Human Polyclonal Hexokinase 2 Primary Antibody für WB - ABIN516456
Lee, Lee, Park, Park, Namgung: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. in Nuclear medicine and molecular imaging 2014
Human Monoclonal Hexokinase 2 Primary Antibody für ELISA, WB - ABIN516457
Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012
Human Polyclonal Hexokinase 2 Primary Antibody für IHC (p), WB - ABIN392755
Laakso, Malkki, Deeb: Amino acid substitutions in hexokinase II among patients with NIDDM. in Diabetes 1995
Show all 3 Pubmed References
SIRT6 (zeige SIRT6 Antikörper) over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1 (zeige ZFP42 Antikörper)/SIRT6 (zeige SIRT6 Antikörper) complex, thereby favouring a regulatory state conducive to diminished transcription
findings suggested that PVT1 contributes to osteosarcoma (OS) cell glucose metabolism, cell proliferation, and motility through the miR (zeige MLXIP Antikörper)-497/HK2 pathway, and revealed a novel relation between lncRNA and the alteration of glycolysis in OS cells
High HKII expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.
The EML4 (zeige EML4 Antikörper)-ALK (zeige ALK Antikörper)-mediated upregulation of HIF1alpha (zeige HIF1A Antikörper), HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4 (zeige EML4 Antikörper)-ALK (zeige ALK Antikörper)-positive NSCLC cells.
relevant number of patients with FDG (zeige SMUG1 Antikörper)-PET false-negative multiple myeloma and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
High HK2 expression is associated with prostate cancer.
Metformin downregulated both endogenous and exogenous UCA1 expression, leading to the inhibition of mammalian target of rapamycin (zeige FRAP1 Antikörper)-signal transducer and activator of transcription 3 (zeige STAT3 Antikörper)-hexokinase 2 signaling pathway. Our study provided the first evidence that metformin inhibited proliferation and glycolysis in cancer cells through regulation of long non-coding RNA UCA1
AKT (zeige AKT1 Antikörper) inhibition blocks miR (zeige MLXIP Antikörper)-124 silencing-induced AKT1 (zeige AKT1 Antikörper)/2, glucose transporter 1 (zeige SLC2A1 Antikörper), hexokinase II activation, cell proliferation, and glycolytic or energy metabolism changes. In summary, this study demonstrated that miR (zeige MLXIP Antikörper)-124 is able to inhibit proliferation, glycolysis, and energy metabolism, potentially by targeting AKT1 (zeige AKT1 Antikörper)/2-glucose transporter 1 (zeige SLC2A1 Antikörper)/hexokinase II in non-small cell lung cancer cells.
Results from the simulations show that HK2 binding restricts the movement of the VDAC1 (zeige VDAC1 Antikörper) N-terminal helix. As a result, VDAC1 (zeige VDAC1 Antikörper) is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (zeige SIRT3 Antikörper) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten (zeige PTEN Antikörper)/p53 (zeige TP53 Antikörper) mutations. HK2 is required for Pten (zeige PTEN Antikörper)-/p53 (zeige TP53 Antikörper)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (zeige SLC2A1 Antikörper) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (zeige ROS1 Antikörper) accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (zeige AKT1 Antikörper).
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, HK II
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, likely hexokinase II