anti-Ratte (Rattus) CHUK Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended CHUK Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) Antikörper
  • ikk
  • ikk1
  • ikka
  • ikkalpha
  • CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • IKKA
  • NFKBIKA
  • TCF16
  • AI256658
  • Chuk1
  • Fbx24
  • Fbxo24
  • Ikka
  • zgc:56539
  • conserved helix-loop-helix ubiquitous kinase
  • chuk
  • CHUK
  • Chuk
Epitop
AA 555-585
50
30
17
15
15
14
11
11
10
9
9
9
8
8
7
7
7
6
5
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
346
152
104
20
12
11
10
7
6
5
5
4
2
1
Wirt
Kaninchen
267
82
12
1
Klonalität
Polyklonal
Konjugat
Dieser CHUK Antikörper ist unkonjugiert
15
11
11
9
8
8
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
312
150
89
76
61
47
43
29
25
19
9
5
3
3
2
2
1
1
1
Optionen
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Bilder

Produktnummer ABIN681508
315,94 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN902065 IF (p) Alexa Fluor 350 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN902066 IF (p) Alexa Fluor 488 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN902067 IF (p) Alexa Fluor 555 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN2814705 IF (p) Alexa Fluor 594 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN902068 IF (p) Alexa Fluor 647 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN681511 IF (p) Cy3 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN681512 IF (p) Cy5 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN681513 IF (p) Cy5.5 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN681514 IF (p) Cy7 Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN681515 IF (p) FITC Rabbit IgG AA 555-585 Anmelden zum Anzeigen Polyclonal
1 ABIN879733 IF (p) Alexa Fluor 350 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN879731 IF (p) Alexa Fluor 488 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN879732 IF (p) Alexa Fluor 555 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN2814706 IF (p) Alexa Fluor 594 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN879734 IF (p) Alexa Fluor 647 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN743276 IF (p) Cy3 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN743277 IF (p) Cy5 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN743278 IF (p) Cy5.5 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN743279 IF (p) Cy7 Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal
1 ABIN743280 IF (p) FITC Rabbit IgG pTyr463 Anmelden zum Anzeigen Polyclonal

anti-CHUK Antikörper für Immunofluorescence (Paraffin-embedded Sections) mit den meisten Publikationen

Ähnliche anti-CHUK Antikörper

Applikation / Reaktivität Ratte (Rattus) Maus
Chromatin Immunoprecipitation (ChIP) 2 Antikörper 2 Antikörper
ELISA 18 Antikörper 32 Antikörper
Enzyme Immunoassay (EIA) 2 Antikörper 2 Antikörper
Flow Cytometry (FACS) 2 Antikörper 19 Antikörper
Immunocytochemistry (ICC) 4 Antikörper
Immunofluorescence (IF) 7 Antikörper
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 26 Antikörper
Immunohistochemistry (IHC) 41 Antikörper
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 34 Antikörper
Immunoprecipitation (IP) 12 Antikörper
Proximity Ligation Assay (PLA) 1 Antikörper
Simple Western (SimWes) 2 Antikörper
Western Blotting (WB) 70 Antikörper
Cytometry by Time of Flight (CyTOF) 1 Antikörper

General

Antigen conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) Antikörper
Epitop AA 555-585
(50), (30), (17), (15), (15), (14), (11), (11), (10), (9), (9), (9), (8), (8), (7), (7), (7), (6), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(346), (152), (104), (20), (12), (11), (10), (7), (6), (5), (5), (4), (2), (1)
Wirt Kaninchen
(267), (82), (12), (1)
Klonalität
Polyklonal
Konjugat Dieser CHUK Antikörper ist unkonjugiert
(15), (11), (11), (9), (8), (8), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(312), (150), (89), (76), (61), (47), (43), (29), (25), (19), (9), (5), (3), (3), (2), (2), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CHUK Antikörper

Target Details CHUK Anwendungsinformationen Handhabung ProductDetails: References for anti-CHUK antibody (ABIN681508) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IKK alpha
Isotyp IgG

Target Details CHUK

Produktdetails anti-CHUK Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-CHUK antibody (ABIN681508) Bilder zurück nach oben
Antigen
Andere Bezeichnung Ikk alpha (CHUK Antibody Abstract)
Hintergrund

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, IKK1, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, Transcription factor 16, TCF-16, CHUK, IKKA, TCF16

Gen-ID 1147
UniProt O15111
Forschungsgebiet Immunology, Innate Immunity, Atherosclerosis, Apoptosis/Necrosis, Transcription Factors
Pathways PI3K-Akt Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-CHUK Antikörper Target Details CHUK Handhabung ProductDetails: References for anti-CHUK antibody (ABIN681508) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CHUK Antikörper Target Details CHUK Anwendungsinformationen ProductDetails: References for anti-CHUK antibody (ABIN681508) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

ProductDetails: References for anti-CHUK antibody (ABIN681508)

Produktdetails anti-CHUK Antikörper Target Details CHUK Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Huang, Yang, Wang, Ma, Cui, Huang, Sheng, Weng, Xu: "Immunostimulatory activity of protein hydrolysate from oviductus ranae on macrophage in vitro." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 180234, 2015

Luo, Yang, Tang, Yao, Kong, He, Zhou: "Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats." in: International immunopharmacology, Vol. 28, Issue 1, pp. 744-50, 2015

Bilder

Produktdetails anti-CHUK Antikörper Target Details CHUK Anwendungsinformationen Handhabung ProductDetails: References for anti-CHUK antibody (ABIN681508) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-CHUK Antikörper (conserved Helix-Loop-Helix Ubiquitous Kinase) (AA 555-585) (ABIN681508) Formalin-fixed and paraffin-embedded mouse lung labeled with Rabbit Anti-IKK alpha Po...