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Results indicate that AKT2 modulates pulmonary fibrosis through inducing TGF-beta1 (zeige TGFB1 ELISA Kits) and IL-13 (zeige IL13 ELISA Kits) production by macrophages, and inhibition of AKT2 may be a potential strategy for treating Idiopathic pulmonary fibrosis.
Sirt1 (zeige SIRT1 ELISA Kits) significantly reduced the levels of raptor (zeige RPTOR ELISA Kits) and inactivated mammalian target of rapamycin (mTOR (zeige FRAP1 ELISA Kits))C1 signal by interacting with Akt2.
This review summarises and discusses the consequences of genetic deletions of Akt (zeige AKT1 ELISA Kits) isoforms in adult mice and their implications for cancer therapy. Whereas combined Akt1 (zeige AKT1 ELISA Kits) and Akt2 rapidly induced mortality, hepatic Akt (zeige AKT1 ELISA Kits) inhibition induced liver injury that promotes hepatocellular carcinoma.
Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor (zeige ARHGEF12 ELISA Kits) FLJ00068 in Akt2-mediated insulin (zeige INS ELISA Kits) signaling in mouse skeletal muscle.
BAY 1125976 is a potent and highly selective allosteric AKT1 (zeige AKT1 ELISA Kits)/2 inhibitor.
AKT2 inhibition induces a unique mitochondrial-dependent DNA degradation pathway by activating nucleus translocation of AIF (zeige AIFM1 ELISA Kits) and EndoG (zeige ENDOG ELISA Kits) during cardiac ischemia.
Akt2 ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 (zeige NFE2L2 ELISA Kits) activation and mitochondrial homeostasis.
Loss of Akt2 enhanced lung tumor development.
Akt2(-/-) mice survive hepatic Akt1 (zeige AKT1 ELISA Kits) deletion but all develop spontaneous hepatocellular carcinoma. They are insulin (zeige INS ELISA Kits) resistant. Akt2(-/-) mice are not resistant to diethylnitrosamine hepatocarcinogenesis. They have a high incidence of lung metastasis.
rescued the hepatic regenerative capability in Akt1 (zeige AKT1 ELISA Kits)-deficient and Akt2-deficient mice
the direct interaction of AKT2 and EF2 (zeige EEF2 ELISA Kits) was found to be dynamically regulated in embryonic rat cardiomyocytes
Data identify MTSS1 as a new Akt2-regulated gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 in CRC (zeige CALR ELISA Kits) cells.
Akt2, Erk2 (zeige MAPK1 ELISA Kits), and IKK1 (zeige CHUK ELISA Kits)/2 phosphorylate Bcl3 (zeige BCL3 ELISA Kits), converting Bcl3 (zeige BCL3 ELISA Kits) into a transcriptional coregulator by facilitating its recruitment to DNA.
The p.Glu17Lys mutation of AKT2 confers low-level constitutive activity upon the kinase and produces hypoglycemia with suppressed fatty acid release from adipose tissue, but not fatty liver, hypertriglyceridemia, or elevated hepatic de novo lipogenesis.
Studies provide evidence that AKT2 counteracts oxidative-stress-induced (zeige SQSTM1 ELISA Kits) apoptosis and is required for alpha-beta thymocyte survival and differentiation. Also, it plays a critical role in antagonizing cardiomyocyte apoptosis. [review]
Akt2 role in the human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation
High expressions of AKT1 (zeige AKT1 ELISA Kits) and AKT2 through possible relation with androgen may cause granulosa cells dysfunction in the +HA PCOS patients.
This study demonstrates novel regulatory circuits involving miR (zeige MLXIP ELISA Kits)-148a-3p/ERBB3 (zeige ERBB3 ELISA Kits)/AKT2/c-myc (zeige MYC ELISA Kits) and DNMT1 (zeige DNMT1 ELISA Kits) that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
Both in our animal model and in human Age-related macular degeneration (AMD (zeige AMD1 ELISA Kits)), the AKT2-NF-kappaB (zeige NFKB1 ELISA Kits)-LCN-2 (zeige LCN2 ELISA Kits) signalling axis is involved in activating the inflammatory response.
Study reports that Appl1 (zeige APPL1 ELISA Kits) regulates the activity of Akt (zeige AKT1 ELISA Kits) and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
akt2 has a role in an integrative pathway directly linking glucose, Glut1 (zeige SLC2A1 ELISA Kits) expression, and activation of apoptosis
Profilin (zeige PFN1 ELISA Kits)-dependent dissociation of G-actin (zeige ACTB ELISA Kits)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK (zeige ILK ELISA Kits)) in the lamellipodia.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
v-akt murine thymoma viral oncogene homolog 2
, RAC-beta serine/threonine-protein kinase
, AKT2 kinase
, RAC-beta serine/threonine-protein kinase-like
, serine/threonine protein kinase
, PKB beta
, RAC-beta serine/threonine protein kinase
, protein kinase Akt-2
, protein kinase B beta
, protein kinase B, beta
, murine thymoma viral (v-akt) homolog-2
, rac protein kinase beta
, RAC protein kinase beta RAC-PK beta
, murine thymoma viral (v-akt) oncogene homolog 2
, thymoma viral proto-oncogene 2
, PKB beta-A
, RAC-beta serine/threonine-protein kinase A
, protein kinase Akt-2-A
, protein kinase B, beta-A
, protein kinase B