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This study aimed to lay the groundwork to further study of Bhlhe40 function at myogenesis and adipogenesis in bovine and should significantly contribute to cattle breeding and genetics through MAS (zeige MAS1 Proteine) program
Expression of DEC1 is evolutionally conserved in zebrafish.
High BHLHE40 expression is associated with glioblastomas.
STRA13 may be essential for the progression of atopic dermatitis by interacting with hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-148b and hsamiR- 152.
BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed. The assay revealed high demethylation in activated NK cells and low demethylation in naive NK, T- and B-cells. We conclude the NK cell methylome is plastic with potential for remodeling.
findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo
Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 (zeige HDAC2 Proteine) and modulates the efficacy of HDAC (zeige HDAC3 Proteine) inhibitors in growth suppression and keratinocyte differentiation.
DEC1 expression is correlated with HIF-1alpha (zeige HIF1A Proteine) protein in gastric cancer cell line.
The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.
IL-1beta (zeige IL1B Proteine) can induce DEC1 and HIF-1alpha (zeige HIF1A Proteine) protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt (zeige AKT1 Proteine) phosphorylation.
DEC1 controls the response of p53 (zeige TP53 Proteine)-dependent cell survival vs. cell death to a stress signal through MIC-1 (zeige C18orf8 Proteine)
findings suggest that the repression of CYP3A4 (zeige CYP3A4 Proteine) by IL-6 (zeige IL6 Proteine) is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 (zeige CYP3A4 Proteine) to form CCCTGC-DEC1 complex
These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-gamma (zeige IFNG Proteine) production in iNKT cells.
Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX-IL-1 (zeige IL1A Proteine)-Bhlhe40 pathway active in experimental autoimmune encephalomyelitis.
Collectively, the data obtained in this study suggest that DEC1 is a novel negative regulator of hepatic FGF21 (zeige FGF21 Proteine) expression
establishes a crucial role of Bhlhe40 in mediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of Bhlhe40 or p53 (zeige TP53 Proteine) may facilitate muscle regeneration after ischemic injuries
There was an inverse relationship between DEC1 expression and AMPK (zeige PRKAA1 Proteine) activity. Our results suggest that DEC1 negatively regulates AMPK (zeige PRKAA1 Proteine) activity via LKB1 (zeige STK11 Proteine)
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
Data indicate that bHLH transcription factors Bhlhe40 interacts with PGC-1alpha protein (PGC-1alpha) and represses its transcriptional activity.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 (zeige BHLHE41 Proteine) and SHARP2.
studies indicate that DEC1 is an important regulator of Srebp-1c (zeige SREBF1 Proteine) expression and links circadian rhythm to hepatic lipogenesis. Activation of Dec1 can alleviate the nonalcoholic fatty liver phenotype
Study demonstrates that DEC1 is involved in osteogenesis.
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation.
basic helix-loop-helix domain containing, class B, 2
, class B basic helix-loop-helix protein 2
, class E basic helix-loop-helix protein 40
, differentially expressed in chondrocytes 1
, differentially expressed in chondrocytes protein 1
, differentiated embryo chondrocyte expressed gene 1
, enhancer-of-split and hairy-related protein 2
, stimulated by retinoic acid gene 13 protein
, bHLH protein DEC1
, FANCM-interacting histone fold protein 2
, Fanconi anemia-associated polypeptide of 10 kDa
, centromere protein X
, stimulated by retinoic acid gene 13 protein homolog
, Class B basic helix-loop-helix protein 2
, basic helix-loop-helix domain containing class B2 protein
, stimulated by retinoic acid 13 homolog
, basic helix-loop-helix family, member e40
, class E basic helix-loop-helix protein 40-like
, transmembrane protein 2
, E47 interaction protein 1
, basic helix-loop-helix domain containing, class B2
, cytokine response gene 8
, eip1 (E47 interaction protein 1)
, enhancer-of split and hairy-related protein 2
, stimulated by retinoic acid 14