rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) Peptid

Details zu Produkt Nr. ABIN1541270, Anbieter: Anmelden zum Anzeigen
Proteinname
  • ARHGEF4
  • ASEF
  • ASEF1
  • GEF4
  • STM6
  • 9330140K16Rik
  • Asef
  • ENSMUSG00000070955
  • Rho guanine nucleotide exchange factor (GEF) 4
  • Rho guanine nucleotide exchange factor 4
  • ARHGEF4
  • arhg4
  • Arhgef4
Protein Region
N-Term
Spezies
Human, Maus
1
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Geblockter Antikörper anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) Antikörper (ABIN2787993)
Sequenz ADDYEAPRAG AREADDSGPE AQSCKDQMRT NVINEILSTE RDYIKHLRDI
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-Arhgef4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund Arhgef4 acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion By similarity. It is required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Arhgef4 is involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Alias Symbols: 9330140K16Rik, Asef, ENSMUSG00000070955

Protein Size: 484
Molekulargewicht 57 kDa
Gen-ID 226970
NCBI Accession NM_183019, NP_898840
UniProt Q7TNR9
Applikationshinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.