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rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) Peptid

ARHGEF4 Reaktivität: Human, Maus Wirt: Synthetic BP, WB
Produktnummer ABIN1541270
  • Target Alle ARHGEF4 Produkte
    ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
    Protein Region
    N-Term
    Spezies
    Human, Maus
    Quelle
    • 2
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    ADDYEAPRAG AREADDSGPE AQSCKDQMRT NVINEILSTE RDYIKHLRDI
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-Arhgef4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
    Synonyme
    ARHGEF4 Peptide, ASEF Peptide, ASEF1 Peptide, GEF4 Peptide, STM6 Peptide, 9330140K16Rik Peptide, Asef Peptide, ENSMUSG00000070955 Peptide, Rho guanine nucleotide exchange factor 4 Peptide, uncharacterized LOC100470646 Peptide, rho guanine nucleotide exchange factor 4 Peptide, Rho guanine nucleotide exchange factor (GEF) 4 Peptide, ARHGEF4 Peptide, arhg4 Peptide, LOC100470646 Peptide, LOC100544917 Peptide, Arhgef4 Peptide
    Hintergrund
    Arhgef4 acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion By similarity. It is required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Arhgef4 is involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

    Alias Symbols: 9330140K16Rik, Asef, ENSMUSG00000070955

    Protein Size: 484
    Molekulargewicht
    57 kDa
    Gen-ID
    226970
    NCBI Accession
    NM_183019, NP_898840
    UniProt
    Q7TNR9
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