RAB27A Proteine (RAB27A)

Bezeichnung:
RAB27A, Member RAS Oncogene Family Proteine (RAB27A)
Auf www.antikoerper-online.de finden Sie aktuell 17 RAB27A, Member RAS Oncogene Family (RAB27A) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RAB27A Antikörper (119) und RAB27A Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 140 RAB27A Produkte verfügbar.
Synonyme:
2210402C08Rik, 2410003M20Rik, 4933437C11Rik, ash, GS2, HsT18676, MGC80943, MGC89827, RAB27, RAB27A, RAM, zgc:114135
alle Proteine anzeigen Gen GeneID UniProt
RAB27A 5873 P51159
RAB27A 11891 Q9ERI2
RAB27A 50645 P23640

Weitere Synonyme anzeigen

RAB27A Proteine (RAB27A) nach Spezies

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Am meisten referenzierte RAB27A Proteine

  1. Human RAB27A Protein expressed in Escherichia coli (E. coli) - ABIN666995 : Kuroda, Fukuda, Ariga, Mikoshiba: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. in The Journal of biological chemistry 2002 (PubMed)

Weitere Proteine zu RAB27A Interaktionspartnern

Human RAB27A, Member RAS Oncogene Family (RAB27A) Interaktionspartner

  1. RAB27A, RAB27B (zeige RAB27B Proteine) and VPS36 (zeige VPS36 Proteine) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (zeige RAB27B Proteine) and VPS36 (zeige VPS36 Proteine), with RAB27A and RAB27B (zeige RAB27B Proteine) being dependent on VPS36 (zeige VPS36 Proteine).

  2. identified small molecule inhibitors of Rab27a-JFC1 (zeige SYTL1 Proteine) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (zeige HRB Proteine) GTPases and their effectors.

  3. MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.

  4. decreased expression of Rab27A and Rab27B (zeige RAB27B Proteine), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

  5. We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).

  6. Data suggest that microRNA miR (zeige MLXIP Proteine)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (zeige CALR Proteine)) by targeting RAS-related GTP-binding protein (zeige RAB10 Proteine) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (zeige CALR Proteine).

  7. Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.

  8. miR (zeige MLXIP Proteine)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle

  9. Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.

  10. Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma

Mouse (Murine) RAB27A, Member RAS Oncogene Family (RAB27A) Interaktionspartner

  1. Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (zeige CSF2 Proteine)-dependent neutrophil priming is involved.

  2. These results suggest that the dual effector, Noc2 (zeige RPH3AL Proteine), regulates the transition from Rab2a (zeige RAB2A Proteine)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.

  3. Loss of Rab3D (zeige RAB3D Proteine) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (zeige RAB3D Proteine) activity, may contribute to the enhanced release of cathepsin S (zeige CTSS Proteine) in tears of patients with Sjogren's syndrome.

  4. identified small molecule inhibitors of Rab27a-JFC1 (zeige SYTL1 Proteine) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (zeige HRB Proteine) GTPases and their effectors.

  5. The Rab27A regulates CG exocytosis following MII-stage oocyte activation.

  6. MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.

  7. Given that GTP (zeige AK3 Proteine)- and GDP-bound Rab27a regulate exocytosis.

  8. This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (zeige CACNA1D Proteine) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (zeige VEGFA Proteine) secretion by the retinal pigment epithelium.

  9. results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway

  10. Rab27A deficiency shows the increased surface level of c-fms (zeige CSF1R Proteine), and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF (zeige CSF1R Proteine) and RANKL (zeige TNFSF11 Proteine).

RAB27A Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with RAB27A

  • RAB27A, member RAS oncogene family (rab27a)
  • RAB27A, member RAS oncogene family (RAB27A)
  • RAB27A, member RAS oncogene family (rab27a-b)
  • RAB27A, member RAS oncogene family (Rab27a)
  • 2210402C08Rik Protein
  • 2410003M20Rik Protein
  • 4933437C11Rik Protein
  • ash Protein
  • GS2 Protein
  • HsT18676 Protein
  • MGC80943 Protein
  • MGC89827 Protein
  • RAB27 Protein
  • RAB27A Protein
  • RAM Protein
  • zgc:114135 Protein

Bezeichner auf Proteinebene für RAB27A

RAB27A, member RAS oncogene family , Ras-related protein Rab-27A , rab27a, member ras oncogene family , ras-related protein Rab-27A , GTP-binding protein Ram , rab-27 , member RAS oncogene family, RAB27A , ashen , low Mr GTP-binding protein , ram p25 , RAS oncogene family member

GENE ID SPEZIES
444290 Xenopus laevis
453455 Pan troglodytes
493339 Xenopus (Silurana) tropicalis
494641 Xenopus laevis
570907 Danio rerio
5873 Homo sapiens
606749 Sus scrofa
618035 Bos taurus
11891 Mus musculus
50645 Rattus norvegicus
608699 Canis lupus familiaris
415410 Gallus gallus
101086976 Felis catus
101122791 Ovis aries
100720981 Cavia porcellus
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