Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
Findings suggest that H. pylori infectionis a driving force of gastric cardia carcinogenesis by upregulating caudal-related homeobox (zeige Lbx1 Proteine) transcription factor 2 (zeige HNF1B Proteine) (CDX2) and inducing inflammation.
Data show that a two-marker panel of p40 (zeige IL9 Proteine) (DeltaNp63) and CDX2 is highly sensitive and specific.
our findings demonstrated that MDR1 expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 (zeige LAMC2 Proteine) in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (zeige TNF Proteine) is present.
Cytapheresis might induce CDX2 expression without affecting the cell proliferation, thus resulting in mucosal healing with goblet cell restoration.
SOX2 (zeige SOX2 Proteine) expression induces a cellular stem cell state in human colorectal cancer (CRC (zeige CALR Proteine)) with a decreased expression of CDX2. Furthermore, a down-regulated expression of CDX2 results in a poor patient prognosis in CRC (zeige CALR Proteine).
A small subset (5%) of hepatocellular carcinomas are CDX2 positive.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (zeige HNF4A Proteine) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (zeige HNF4A Proteine) in human biopsy samples.
Colon cancer cells expressing CDX2 are less deformable, a feature that has been shown to correlate with poor metastatic potential.
Results show that CDX2 and Fbw7 expression is inversely correlated during colon cell differentiation and that CDX2 expression is regulated by Fbw7 in a GSK3b-dependent manner.
Data show that SLC7A7 (zeige Slc7a7 Proteine) is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 (zeige Slc7a7 Proteine) promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (zeige POU5F1 Proteine), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (zeige POU5F1 Proteine) in embryo of mammals other than mouse
including Wnt (zeige WNT2 Proteine) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (zeige CDX1 Proteine)/Hox (zeige MSH2 Proteine) and T Brachyury (zeige TBX1 Proteine) transcriptional networks controls differential axial growth during vertebrate trunk elongation
Cdx (zeige CDX1 Proteine) members interact with the SWI (zeige SMARCA1 Proteine)-SNF (zeige SNRPA Proteine) complex and make direct contact with Brg1 (zeige SMARCA4 Proteine), a catalytic member of SWI (zeige SMARCA1 Proteine)-SNF (zeige SNRPA Proteine). Both Cdx2 and Brg1 (zeige SMARCA4 Proteine) co-occupy a number of Cdx (zeige CDX1 Proteine) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (zeige SMARCA4 Proteine) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox (zeige MSH2 Proteine) gene.
Cdx1 (zeige CDX1 Proteine)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (zeige ADCY10 Proteine) and a block in hematopoietic differentiation from yolk sac (zeige ADCY10 Proteine)-derived cells in culture.
this study shows that Aloe vera (zeige IGF2BP3 Proteine) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (zeige HOXB7 Proteine) and Cdx2 in colon cancer cells.
CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs (zeige NFS1 Proteine) may be activated or repressed.
cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.
findings illuminated a role for NOD1 (zeige NOD1 Proteine) signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2