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Human Cathepsin D ELISA Kit für Sandwich ELISA - ABIN417608
Huber-Lang, Denk, Fulda, Erler, Kalbitz, Weckbach, Schneider, Weiss, Kanse, Perl: Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. in Molecular immunology 2012
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Vitner, Dekel, Zigdon, Shachar, Farfel-Becker, Eilam, Karlsson, Futerman: Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. in Human molecular genetics 2010
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Li, Lu, Nguyen, Bae, Chapman, Feng, Hawkins, Pessin, Sears, Nguyen, Amidi, Watkins, Nguyen, Olefsky: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. in The Journal of biological chemistry 2010
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Schwartz-Roberts, Shajahan, Cook, Wärri, Abu-Asab, Clarke: GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. in Molecular cancer therapeutics 2013
Poliakov, Strunnikova, Jiang, Martinez, Parikh, Lakkaraju, Thomas, Brooks, Redmond: Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells. in Molecular vision 2014
These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.
apoptosis is accompanied by degradation of the cysteine cathepsin inhibitor stefin B (StfB (zeige CSTB ELISA Kits)). CatD did not exhibit a crucial role in this step. However, this degradation was partially prevented through pre-incubation with the antioxidant N-acetyl cysteine
The lysosomal enzyme cathepsin D (CTSD) mediates the proteolytic cleavage of PSAP (zeige PSAP ELISA Kits) precursor into saposins A-D. Myc (zeige MYC ELISA Kits)-CLN3 (zeige CLN3 ELISA Kits) colocalized with CTSD and activity of CTSD decreased as myc (zeige MYC ELISA Kits)-CLN3 (zeige CLN3 ELISA Kits) expression increased, and clearly decreased under hyperosmotic conditions
Study demonstrate that PGRN (zeige GRN ELISA Kits) interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN (zeige GRN ELISA Kits) may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP ELISA Kits) aggregation observed in frontotemporal lobar degeneration with GRN (zeige GRN ELISA Kits) mutations.
The S-nitrosation of a non-catalytic cysteine residue in the lysosomal aspartyl protease cathepsin D (CTSD) inhibited proteolytic activation.
Secreted PGRN (zeige GRN ELISA Kits) is incorporated into cells via sortilin (zeige SORT1 ELISA Kits) or cation-independent mannose 6-phosphate receptor (zeige IGF2R ELISA Kits), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (zeige GRN ELISA Kits) levels led to a cell-type-specific increase of insoluble TDP-43 (zeige TARDBP ELISA Kits). In the brain tissue of FTLD-TDP patients with PGRN (zeige GRN ELISA Kits) deficiency, CTSD and phosphorylated TDP-43 (zeige TARDBP ELISA Kits) accumulated in neurons
CTSD, in need of its catalytic activity, may promote proliferation in advanced glycation end products-treated human umbilical vein endothelial cells independent of the autophagy-lysosome pathway.
Cathepsin D facilitates the TRAIL-induced apoptosis of MDA-MB-231 breast cancer cells in enzymatic activity-dependent manner. Caspase-8 (zeige CASP8 ELISA Kits) and Bid (zeige BID ELISA Kits) proteins are the CD targets. The modulatory role of CD in cell response to TRAIL was also confirmed in another breast cancer cell line SKBR3.
Gene expression level of CTSD is significantly higher in AD patients when compared to normal controls.
There was a significant difference between groups with and without endothelial dysfunction in terms of cathepsin D levels, and negative and significant correlations were found between brachial artery FMD (zeige FLNA ELISA Kits)% and cathepsin D levels. Cathepsin D, which is known to be associated with atherosclerosis, may play a role in the proce
Serum CTSB (zeige CTSB ELISA Kits) and CTSD concentrations were found to have a diagnostic value in NPC (zeige NPC1 ELISA Kits). However, the CTSB (zeige CTSB ELISA Kits) and CTSD serum levels had no prognostic role for the outcome in nasopharyngeal carcinoma patients.
These results suggested that Purkinje cells (PCs) were more vulnerable to CTSD deficiency in lysosomes than to autophagy impairment, and this vulnerability does not depend on the severity of axonal swelling.
Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (zeige DNAJC5 ELISA Kits)-dependent cathepsins B and L, but not the Asp (zeige C3 ELISA Kits)-dependent cathepsin D.
these results suggest that inhibition of lysosomal proteases, such as CtsD, could be a new therapeutic approach to reduce renal fibrosis and slow progression of chronic kidney disease.
The neuroectoderm specific cathepsin D (Ctsd) knock-out mice survived about 5.5 days longer.
Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).
This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.
Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB (zeige ALMS1 ELISA Kits).
Mouse prolactin (zeige PRL ELISA Kits) was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin (zeige PRL ELISA Kits) fragment and Cath D expression increased during mammary gland involution.
Association of polymorphisms in calpain 1 (zeige CAPN1 ELISA Kits), (mu/I) large subunit, calpastatin (zeige CAST ELISA Kits), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease
The effect of heavy metal cations on the activity of cathepsin D, was studied.
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
, cathepsin D
, aspartic protease
, cathepsin d
, preprocathepsin D
, ceroid-lipofuscinosis, neuronal 10
, lysosomal aspartyl peptidase
, lysosomal aspartyl protease
, cathepsin D (lysosomal aspartyl peptidase)
, cathepsin D (lysosomal aspartyl protease)
, prepro-cathepsin D, prepro-CD