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Human Stratifin ELISA Kit für Sandwich ELISA - ABIN852172
Chen, Chung, Wu, Ng, Yu, Tsai, Chang, Liang, Tsui, Chen: Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer. in Molecular & cellular proteomics : MCP 2015
Human Stratifin ELISA Kit für Sandwich ELISA - ABIN422790
Zeiler, Straube, Lundberg, Uhlen, Mann: A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines. in Molecular & cellular proteomics : MCP 2012
This data indicates that 14-3-3sigma contributes to P-gp (zeige ABCB4 ELISA Kits) overexpression through interaction with PXR (zeige NR1I2 ELISA Kits) with rifampin and paclitaxel treatment.
The impact of AKT1 (zeige AKT1 ELISA Kits) on glucocorticoid receptor (GR (zeige NR3C1 ELISA Kits))-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (zeige YWHAQ ELISA Kits), was examined.
Data showed that 14-3-3s contributed to ionizing radiation (IR) resistance possibly by regulating cell cycle progression and non-homologous end joining repair of IR-induced DNA double strand breaks via regulating the expression of Chk2 (zeige CHEK2 ELISA Kits) and PARP1 (zeige PARP1 ELISA Kits). These findings suggest that 14-3-3s may be an upstream master regulator in chemo and radiation resistance and cancer cell survival.
Structural basis for the interaction of a human HSPB6 (zeige HSPB6 ELISA Kits) protein with the 14-3-3 (zeige YWHAQ ELISA Kits) universal signaling regulator has been reported.
Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 (zeige YWHAQ ELISA Kits) binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 (zeige YWHAQ ELISA Kits) isoforms of a different type.
Data suggest that 14-3-3 sigma protein exhibits two individual secondary binding sites for peptide fragments of TAZ (zeige TAZ ELISA Kits) protein; these two pockets appear to be part of at least three physiologically relevant and structurally characterized 14-3-3 protein (zeige YWHAE ELISA Kits)-protein interaction interfaces.
These results suggest that SFN facilitates lung tumor development and progression. SFN appears to be a novel oncogene (zeige RAB1A ELISA Kits) with potential as a therapeutic target
SFN regulates cancer metabolic reprogramming. It opposes tumor-promoting metabolic programs by enhancing c-Myc (zeige MYC ELISA Kits) poly-ubiquitination and degradation. SFN suppresses cancer glycolysis, glutaminolysis, and mitochondrial biogenesis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (zeige TUBB ELISA Kits) cytoskeleton mediated by binding Tau protein.
K17 (zeige KRT17 ELISA Kits) expression is accompanied by cytoplasmic expression of 14-3-3 sigma, indicative of their functional relationship in oral squamous cell carcinoma
14-3-3sigma stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion.
these data provides the first evidence that 14-3-3 sigma is a Smad3 (zeige SMAD3 ELISA Kits)-dependent target gene of TGF-beta1 (zeige TGFB1 ELISA Kits).
14-3-3sigma plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3beta (zeige GSK3b ELISA Kits) and enhancing Wnt (zeige WNT2 ELISA Kits)-signaled GSK-3beta (zeige GSK3b ELISA Kits) inactivation.
study shows that p63 and 14-3-3sigma play opposing roles in the development of skin tumors and that the accumulation of p63 is essential for Ras/14-3-3sigma mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
Data show that endogenous 14-3-3sigma protein formed a complex with FOXO1 (zeige FOXO1 ELISA Kits) protein.
14-3-3 sigma is required for TGF-beta1 (zeige TGFB1 ELISA Kits)-mediated growth inhibition in mouse mammary epithelial cells.
14-3-3 sigma is needed for normal hair growth
14-3-3sigma is critical for regulating corneal epithelial proliferation and differentiation by regulating Notch (zeige NOTCH1 ELISA Kits) signaling activity.
14-3-3 (zeige YWHAQ ELISA Kits) can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 (zeige YWHAQ ELISA Kits) complex in the cytoplasm.
Efp (zeige TRIM25 ELISA Kits) targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
, 14-3-3 protein sigma
, epithelial cell marker protein 1
, 14-3-3 sigma protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide