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the expression of certain TAM (zeige CCNA1 Proteine) components was reduced as a result of prolonged degradation of MYD88 by Porphyromonas gingivalis infection.
MYD88 expression in subcutaneous adipose tissue of obese subjects could be associated with the development of components of Metabolic syndrome.
Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 mutations.
Mutation in the MYD88 gene is associated with lymphoplasmacytic lymphoma and chronic lymphocytic leukemia.
the polymorphisms in TLR-MyD88-NF-kappaB (zeige NFKB1 Proteine) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (zeige TLR4 Proteine) TIR domains and induce formation of MyD88 assemblies.
data show that in pericytes, MyD88 and IRAK4 (zeige IRAK4 Proteine) are key regulators of 2 major injury responses: inflammatory and fibrogenic.
Data indicate that 64 patients (57.1%) carried the myeloid differentiation factor 88 protein (MYD88) L265P mutation and 14 patients (12.5%) carried the chemokine (C-X-C motif) receptor 4 (CXCR4) WHIM (zeige CXCR4 Proteine)-like mutation.
HCK (zeige HCK Proteine) represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88.
We found an that enhanced expression of the TLR4 (zeige TLR4 Proteine)-MyD88-NF-kB pathway occurs in GDM placentae, which positively correlates with heightened local IR in placentae and higher maternal hyperglycemia. The TLR4 (zeige TLR4 Proteine)/MyD88/NF-kB pathway may play a potential role in the development of IR in placentae of GDM.
TLR9 (zeige TLR9 Proteine)/MyD88 signaling selectively in CD11c (zeige ITGAX Proteine)(+) dendritic cells (DCs) strongly enhances murine cytomegalovirus clearance.
Taken together, the data demonstrate a critical role of MyD88 in DCs and of IL-33 (zeige IL33 Proteine) signaling via ST2 (zeige SULT2A1 Proteine) in MC903-induced Atopic dermatitis (AD). These data suggest that IL-33 (zeige IL33 Proteine)/IL-33R may be a therapeutic target of AD.
CD103 (zeige ITGAE Proteine)(-)CD11b (zeige ITGAM Proteine)(+) dendritic cells instruct both IFNgamma(+) and IL-17 (zeige IL17A Proteine)(+) T cells, and only the IL-17 (zeige IL17A Proteine)-inducing antigen presenting cell functions require MyD88.
Distinct mechanisms downstream of TLR4 (zeige TLR4 Proteine) signaling mediate myelosuppression and hematopoietic stem cell exhaustion during sepsis through unique effects of MyD88 and TRIF (zeige RNF138 Proteine).
these data show that both Myd88 and TRIF (zeige RNF138 Proteine) are necessary for Th17 differentiation in the lungs in response to immunization with lipopolysaccharide
this study shows that MyD88-dependent myeloid-derived suppressor cells expansion from donor bone marrow is critical for protection against fatal intestinal graft-vs.-host disease
This study reveals that Ehrlichia-induced liver injury and toxic shock are mediated by MyD88-dependent inflammasome activation and autophagy inhibition.
MyD88 signaling in lysozyme (zeige LYZ Proteine) M and CD11c (zeige ITGAX Proteine)-expressing myeloid cells, as well as in pulmonary epithelial cells, is critical to restore inflammatory cytokine and antimicrobial peptide (zeige cAMP Proteine) production, leading to efficient neutrophil recruitment and enhanced bacterial clearance.
These results suggest that S. Typhimurium promotes its systemic growth and dissemination through MyD88 signaling pathways in mesenchymal cells.
a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.
propose that dMyD88 is the functional homolog of TIRAP (zeige TIRAP Proteine) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors
DmMyD88 encodes an essential component of the Toll (zeige TLR4 Proteine) pathway in dorsoventral pattern formation.
We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.
both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (zeige IRAK1 Proteine).
These results suggest that porcine circovirus 2 induces IL-8 (zeige IL8 Proteine) secretion via the TLR2/MyD88/NF-kappaB (zeige NFKB1 Proteine) signalling pathway.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.
These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.
Fish IRF6 (zeige IRF6 Proteine) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (zeige TBK1 Proteine), suggesting that differences in the IRF6 (zeige IRF6 Proteine) regulation pattern exist between lower and higher vertebrates.
DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (zeige IRF1 Proteine) as a positive IFN regulator.
MyD88 signaling has an important protective role during early pathogenesis.
MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.
L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation
Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.
The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.
MyD88 plays a functional role in transducing LPS (zeige IRF6 Proteine) signaling from TLR-4 (zeige TLR4 Proteine) to downstream effector molecules involved in NF-kappaB (zeige NFKB1 Proteine) activation
MyD88 interacts with interferon (zeige IFNA Proteine) regulatory factor (IRF) 3 (zeige IRF3 Proteine) and IRF7 (zeige IRF7 Proteine) in Atlantic salmon (Salmo salar)
the salmon MyD88 was cloned and its expression was analysed.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
myeloid differentiation primary response gene (88)
, myeloid differentiation primary response protein MyD88
, myeloid differentiation primary response protein MyD88-B
, Toll/IL-1 receptor binding protein MyD88-B
, myeloid differentiation primary response gene 88
, myeloid differentiation primary response factor 88
, myeloid differentiation factor 88
, myeloid differentiation primary response protein 88
, myeloid differentiation response protein 88