MYD88 Proteine (MYD88)

Bezeichnung:
Myeloid Differentiation Primary Response Gene (88) Proteine (MYD88)
Auf www.antikoerper-online.de finden Sie aktuell 26 Myeloid Differentiation Primary Response Gene (88) (MYD88) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MYD88 Antikörper (272) und MYD88 Kits (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 363 MYD88 Produkte verfügbar.
Synonyme:
CG2078, Dmel\\CG2078, DmMyd88, dMyd88, EP(2)2535, GB12344, irak-2, kra, LD20892, MGC84928, myd88, myd88d, Myd88F, NV10640, XMyD88, zgc:103541
alle Proteine anzeigen Gen GeneID UniProt
MYD88 4615 Q99836
MYD88 17874 P22366
MYD88 301059 Q6Y1S1

Weitere Synonyme anzeigen

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Am meisten referenzierte MYD88 Proteine

  1. Human MYD88 Protein expressed in Escherichia coli (E. coli) - ABIN1098740 : Kawai, Sato, Ishii, Coban, Hemmi, Yamamoto, Terai, Matsuda, Inoue, Uematsu, Takeuchi, Akira: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. in Nature immunology 2004 (PubMed)
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Weitere Proteine zu MYD88 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.

  2. propose that dMyD88 is the functional homolog of TIRAP (zeige TIRAP Proteine) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors

  3. DmMyD88 encodes an essential component of the Toll (zeige TLR4 Proteine) pathway in dorsoventral pattern formation.

  4. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.

  5. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (zeige IRAK1 Proteine).

Zebrafish Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. Fish IRF6 (zeige IRF6 Proteine) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (zeige TBK1 Proteine), suggesting that differences in the IRF6 (zeige IRF6 Proteine) regulation pattern exist between lower and higher vertebrates.

  2. DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (zeige IRF1 Proteine) as a positive IFN regulator.

  3. MyD88 signaling has an important protective role during early pathogenesis.

  4. MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.

Human Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. the polymorphisms in TLR-MyD88-NF-kappaB (zeige NFKB1 Proteine) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.

  2. Here the authors show that MAL (zeige MAL Proteine) TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (zeige TLR4 Proteine) TIR domains and induce formation of MyD88 assemblies.

  3. data show that in pericytes, MyD88 and IRAK4 (zeige IRAK4 Proteine) are key regulators of 2 major injury responses: inflammatory and fibrogenic.

  4. Data indicate that 64 patients (57.1%) carried the myeloid differentiation factor 88 protein (MYD88) L265P mutation and 14 patients (12.5%) carried the chemokine (C-X-C motif) receptor 4 (CXCR4) WHIM (zeige CXCR4 Proteine)-like mutation.

  5. HCK (zeige HCK Proteine) represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88.

  6. We found an that enhanced expression of the TLR4 (zeige TLR4 Proteine)-MyD88-NF-kB pathway occurs in GDM placentae, which positively correlates with heightened local IR in placentae and higher maternal hyperglycemia. The TLR4 (zeige TLR4 Proteine)/MyD88/NF-kB pathway may play a potential role in the development of IR in placentae of GDM.

  7. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll (zeige TLR4 Proteine)-like receptor signaling pathway, especially toll-like receptor-3 (zeige TLR3 Proteine)-mediated MyD88-independent pathway.We speculated that CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll (zeige TLR4 Proteine)-like receptor pathway

  8. Data suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (zeige IL1B Proteine))-stimulated trans-autophosphorylation of IRAK4 (interleukin-1 receptor-associated kinase 4 (zeige IRAK4 Proteine)) is initiated by MYD88-induced dimerization of IRAK4 (zeige IRAK4 Proteine). In contrast, IRAK1 (interleukin-1 receptor-associated kinase 1 (zeige IRAK1 Proteine)) is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (zeige CDK7 Proteine) in response to IL1B (zeige IL1B Proteine).

  9. our data suggest a new role of MyD88 in the development of glucose intolerance and hepatic steatosis.

  10. In patient population from Southeast Serbia Myd 88 L265 mutation was not responsible for the development of diffuse large B-cell non Hodgkin lymphoma.

Pig (Porcine) Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. These results suggest that porcine circovirus 2 induces IL-8 (zeige IL8 Proteine) secretion via the TLR2/MyD88/NF-kappaB (zeige NFKB1 Proteine) signalling pathway.

  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.

  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.

Cow (Bovine) Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation

  2. Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.

  3. The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.

  4. MyD88 plays a functional role in transducing LPS (zeige IRF6 Proteine) signaling from TLR-4 (zeige TLR4 Proteine) to downstream effector molecules involved in NF-kappaB (zeige NFKB1 Proteine) activation

Atlantic Salmon (Salmo salar) Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. MyD88 interacts with interferon (zeige IFNA Proteine) regulatory factor (IRF) 3 (zeige IRF3 Proteine) and IRF7 (zeige IRF7 Proteine) in Atlantic salmon (Salmo salar)

  2. the salmon MyD88 was cloned and its expression was analysed.

Mouse (Murine) Myeloid Differentiation Primary Response Gene (88) (MYD88) Interaktionspartner

  1. Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma\

  2. These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88, and is not sufficient to prevent bacterial binding.

  3. data show that in pericytes, MyD88 and IRAK4 (zeige IRAK4 Proteine) are key regulators of 2 major injury responses: inflammatory and fibrogenic.

  4. TLR4 (zeige TLR4 Proteine) agonist MPLA potently induced MyD88-dependent signaling. Neutrophil recruitment after multiple injections of MPLA was reliant on MyD88-dependent signaling. MPLA treatment induced expansion of myeloid progenitors in bone marrow and upregulation of CD11b (zeige ITGAM Proteine) and shedding of L-selectin (zeige SELL Proteine) by neutrophils, all of which were attenuated in MyD88-deficient mice.

  5. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3 (zeige TLR3 Proteine)/7/9 in macrophages; macrophages deficient for Tlr3 (zeige TLR3 Proteine)/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll (zeige TLR4 Proteine)-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88)

  6. MyD88 inhibitor ST2825 attenuates acute cardiac rejection and promotes donor-specific hyporesponsiveness in stringent skin transplant models

  7. MyD88 has a divergent requirement for cell survival in non-Tregs and Tregs, and a yet-to-be defined survival-independent requirement for Treg function during the response to alloantigen

  8. The aim of this study was to examine the role of the common TLR adaptor protein myeloid-differentiation factor (MyD) 88 in lung epithelium during host defense against K. pneumoniae-induced pneumonia.

  9. TLR2, TLR4 (zeige TLR4 Proteine) AND MyD88 mediate allergic airway disease (AAD) and Streptococcus pneumoniae-induced suppression of AAD.

  10. miR-23a-5p modulated the innate host defense by promoting mycobacteria survival and inhibiting the activation of autophagy against Mycobacterium tuberculosis through TLR2/MyD88/NF-kappaB pathway by targeting TLR2.

MYD88 Protein Überblick

Protein Überblick

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MYD88

  • myeloid differentiation primary response 88 (MYD88)
  • interleukin-1 receptor-associated kinase 2 (irak2)
  • interleukin-1 receptor-associated kinase 2 (IRAK2)
  • interleukin-1 receptor-associated kinase 2 (LOC100228175)
  • myeloid differentiation primary response gene (88) (myd88-b)
  • myeloid differentiation primary response gene 88 (Myd88)
  • CG2078 gene product from transcript CG2078-RB (Myd88)
  • myeloid differentiation primary response 88 (Myd88)
  • myeloid differentiation primary response gene (88) (MYD88)
  • myeloid differentiation primary response gene (88) (myd88)
  • myeloid differentiation primary response factor 88 (Myd88)
  • myeloid differentiation primary response 88 (myd88)
  • MyD88 adaptor (myd88)
  • myeloid differentiation factor 88 (myd88)
  • myeloid differentiation response protein 88 (myd88)
  • myeloid differentiation primary response gene 88 (myd88)
  • CG2078 Protein
  • Dmel\\CG2078 Protein
  • DmMyd88 Protein
  • dMyd88 Protein
  • EP(2)2535 Protein
  • GB12344 Protein
  • irak-2 Protein
  • kra Protein
  • LD20892 Protein
  • MGC84928 Protein
  • myd88 Protein
  • myd88d Protein
  • Myd88F Protein
  • NV10640 Protein
  • XMyD88 Protein
  • zgc:103541 Protein

Bezeichner auf Proteinebene für MYD88

myeloid differentiation primary response gene (88) , myeloid differentiation primary response protein MyD88 , interleukin-1 receptor-associated kinase-like 2 , interleukin-1 receptor-associated kinase 2 , myeloid differentiation primary response protein MyD88-B , Toll/IL-1 receptor binding protein MyD88-B , CG2078-PA , CG2078-PB , Myd88-PA , Myd88-PB , Myd88F , krapfen , myeloid differentiation primary response gene 88 , myeloid differentiation primary response factor 88 , zMyD88 , myeloid differentiation factor 88 , myeloid differentiation primary response protein 88 , myeloid differentiation response protein 88

GENE ID SPEZIES
4615 Homo sapiens
493227 Xenopus (Silurana) tropicalis
416118 Gallus gallus
100228175 Taeniopygia guttata
734302 Xenopus laevis
17874 Mus musculus
35956 Drosophila melanogaster
301059 Rattus norvegicus
396646 Sus scrofa
403145 Danio rerio
413194 Apis mellifera
420420 Gallus gallus
444881 Bos taurus
460269 Pan troglodytes
477024 Canis lupus familiaris
549591 Xenopus (Silurana) tropicalis
678682 Ovis aries
696494 Macaca mulatta
100118553 Nasonia vitripennis
100134853 Takifugu rubripes
100136123 Oncorhynchus mykiss
100169859 Salmo salar
100305041 Ictalurus punctatus
100616081 Amphimedon queenslandica
575153 Strongylocentrotus purpuratus
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