anti-MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Antikörper

Bezeichnung:
anti-MCF.2 Cell Line Derived Transforming Sequence-Like Antikörper (MCF2L)
Auf www.antikoerper-online.de finden Sie aktuell 54 MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MCF.2 Cell Line Derived Transforming Sequence-Like Proteine (4) und MCF.2 Cell Line Derived Transforming Sequence-Like Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 64 MCF.2 Cell Line Derived Transforming Sequence-Like Produkte verfügbar.
Synonyme:
ARHGEF14, C130040G20Rik, Dbs, GP330, mcf 2l, MCF2L, mKIAA0362, NV11503, Ost
Alle Antikörper anzeigen Gen GeneID UniProt
MCF2L 100361711  
MCF2L 4036 P98164
MCF2L 17207  

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Weitere Synonyme anzeigen

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Weitere Antikörper gegen MCF.2 Cell Line Derived Transforming Sequence-Like Interaktionspartner

Human MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Interaktionspartner

  1. we discovered one novel locus (LRP2 (zeige LRP2 Antikörper); most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).

  2. miR (zeige MLXIP Antikörper)-148b directly down-regulates renal megalin (zeige LRP2 Antikörper) expression.

  3. Exocytosis-mediated urinary C-megalin (zeige LRP2 Antikörper) excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin (zeige LRP2 Antikörper)-mediated lysosomal dysfunction in proximal tubules.

  4. The studies suggest that impaired endocytosis of megalin (zeige LRP2 Antikörper)/cubilin (zeige CUBN Antikörper) ligands, hemoglobin (zeige HBB Antikörper) and albumin (zeige ALB Antikörper), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.

  5. VDR (zeige CYP27B1 Antikörper) and MEGALIN (zeige LRP2 Antikörper) gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.

  6. the main role for placental megalin (zeige LRP2 Antikörper) is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin (zeige LRP2 Antikörper) in the cytotrophoblasts.

  7. specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2 (zeige LRP2 Antikörper)/Akt (zeige AKT1 Antikörper) pathway

  8. abundances of megalin (zeige LRP2 Antikörper) and Dab2 (zeige DAB2 Antikörper) (p = 0.046) were reduced in infected placentas from women with LBW deliveries

  9. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (zeige LRP2 Antikörper) and TSPYL2 (zeige TSPYL2 Antikörper) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  10. A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.

Mouse (Murine) MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Interaktionspartner

  1. the PH domain of Dbs has a role in regulating Rho GTPase (zeige RACGAP1 Antikörper) activation

  2. the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (zeige RACGAP1 Antikörper) association and activation in vitro and one for phosphoinositide binding and GTPase (zeige RACGAP1 Antikörper) interaction in vivo, that together promote Dbs association with membranes.

  3. Dbs is activated by Rac1 at the pleckstrin (zeige PLEK Antikörper) homology domain

  4. Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.

  5. Crystal structure of the DH/PH fragment of Dbs without bound GTPase (zeige RACGAP1 Antikörper)

  6. the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein

  7. Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner

MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Alternative names and synonyms associated with MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L)

  • MCF.2 cell line derived transforming sequence-like (MCF2L) Antikörper
  • MCF.2 cell line derived transforming sequence-like (LOC100361711) Antikörper
  • MCF.2 cell line derived transforming sequence-like (mcf2l.2) Antikörper
  • MCF.2 cell line derived transforming sequence-like (mcf2l) Antikörper
  • low density lipoprotein receptor-related protein 2 (LRP2) Antikörper
  • MCF.2 cell line derived transforming sequence-like (Mcf2l) Antikörper
  • mcf.2 transforming sequence-like (Mcf2l) Antikörper
  • ARHGEF14 Antikörper
  • C130040G20Rik Antikörper
  • Dbs Antikörper
  • GP330 Antikörper
  • mcf 2l Antikörper
  • MCF2L Antikörper
  • mKIAA0362 Antikörper
  • NV11503 Antikörper
  • Ost Antikörper

Bezeichner auf Proteinebene für MCF2L

guanine nucleotide exchange factor DBS , MCF.2 cell line derived transforming sequence-like , coagulation factor VII , guanine nucleotide exchange factor DBS-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , low-density lipoprotein receptor-related protein 2 , megalin , DBL's big sister , MCF2 transforming sequence-like protein , MCF2-transforming sequence-like protein , OST oncogene , mcf.2 transforming sequence-like , Ost gamma , exchange factor for RhoA and Cdc42 , guanine nucleotide exchange factor OSTIII

GENE ID SPEZIES
418748 Gallus gallus
452678 Pan troglodytes
485555 Canis lupus familiaris
505595 Bos taurus
100122691 Nasonia vitripennis
100361711 Rattus norvegicus
100380200 Xenopus (Silurana) tropicalis
100549760 Meleagris gallopavo
100559055 Anolis carolinensis
100606412 Nomascus leucogenys
4036 Homo sapiens
23263 Homo sapiens
117020 Rattus norvegicus
17207 Mus musculus
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