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study defines two classes of HDAC2 targets in human cells, with a dependence of HDAC1 (zeige HDAC1 ELISA Kits) on HDAC2 at one class of targets, and distinguishes unique functions for HDAC2
This study demonstrated that the Expression of HDAC2 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.
The findings suggest that miR (zeige MLXIP ELISA Kits)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 (zeige HIST3H3 ELISA Kits) acetylation.
report the interaction between CFTR (zeige CFTR ELISA Kits) and HDAC2, and its involvement in the development of Ph+ leukemia
Results indicate that HCV core induced epithelial-mesenchymal transition (EMT (zeige ITK ELISA Kits)) by interacting with the transcriptional repressor complex Snail (zeige SNAI1 ELISA Kits)/HDAC1 (zeige HDAC1 ELISA Kits)/2 at the E-cadherin (zeige CDH1 ELISA Kits) promoter, which led to E-cadherin (zeige CDH1 ELISA Kits) repression and increased invasiveness of hepatoma cells.
Coexpression of SALL4 with HDAC1 and/or HDAC2 was associated with PTEN underexpression and a poor prognosis in hepatocellular carcinoma.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP ELISA Kits) and HDAC1-HDAC2 (zeige HDAC1 ELISA Kits) has been described.
USP4 (zeige USP4 ELISA Kits) inhibits p53 (zeige TP53 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) through deubiquitinating and stabilizing HDAC2
Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity.
HDAC2 controls ciliogenesis independently of Kras, which facilitates Aurora A (zeige AURKA ELISA Kits) expression. These studies suggest that HDAC2 is a novel regulator of primary cilium formation in PDAC cells.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Treatment of the haplotype Npr1 (zeige NPR1 ELISA Kits)(+/-) mice with histone deacetylase (zeige HDAC1 ELISA Kits) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (zeige HDAC1 ELISA Kits)/2, NF-kappaB (zeige NFKB1 ELISA Kits) (p65 (zeige NFkBP65 ELISA Kits)), and STAT1 (zeige STAT1 ELISA Kits).
Our study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri (zeige POSTN ELISA Kits)-infarct neurons as well as augmenting neuroinflammation. Thus, precisely targeting histone deacetylase 2 in the window phase provides a novel therapeutic strategy for stroke recovery.
Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac (zeige HDAC3 ELISA Kits) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
provide new insight into the upstream regulation of Sap90/Psd95 (zeige DLG4 ELISA Kits)-associated protein 3 (zeige HSPB3 ELISA Kits) and establish the essential role of striatal Hdac1 (zeige HDAC1 ELISA Kits), Hdac2 and MeCP2 for suppression of repetitive behaviors
this study shows that infection-induced miR (zeige MLXIP ELISA Kits)-21 promotes severe, steroid-insensitive allergic airway disease by suppressing HDAC2
observations suggest that Methamphetamine may induce large-scale transcriptional changes in the Nuc (zeige SREBF2 ELISA Kits). Accumbens by regulating the expression of several histone deacetylases in part, via HDAC2-dependent mechanisms.
We also found that glucocorticoid receptor (GR (zeige NR3C1 ELISA Kits))-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1 (zeige TRPV1 ELISA Kits)(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
YY1-associated factor 1
, transcriptional regulator homolog RPD3
, YY1 transcription factor-binding protein
, histone deacetylase-2