Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
Acute tacrolimus treatment transiently increases hepcidin (zeige HAMP ELISA Kits) in wild-type mice. FKBP12 preferentially targets the BMP receptor (zeige BMPR1A ELISA Kits) ALK2 (zeige ACRV1 ELISA Kits). ALK2 (zeige ACRV1 ELISA Kits) mutants defective in binding FKBP12 increase hepcidin (zeige HAMP ELISA Kits) expression in a ligand-independent manner, through BMP-SMAD (zeige SMAD1 ELISA Kits) signaling.
FKBP51 (zeige FKBP5 ELISA Kits) is a central mediator of chronic pain.
We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function.
Fkbp1a-mediated regulation of Notch1 (zeige NOTCH1 ELISA Kits) plays an important role in intercellular communication between endocardium and myocardium.
FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I Na
the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6 (zeige FKBP1B ELISA Kits), and intracellular calcium dynamics was investigated.
Data show that deletion of FKBP12 increased transforming growth factor-beta receptor activation and SMAD2 (zeige SMAD2 ELISA Kits)/3 signaling.
FKBP12 is a critical regulator of I(Na) and is important for cardiac arrhythmogenic physiology
a trimeric-interaction among calcineurin, FKBP12, and RyR (zeige RYR1 ELISA Kits) is important for the regulation of the RyR (zeige RYR1 ELISA Kits) channel activity and may play an important role in the Ca(2 (zeige CA2 ELISA Kits)+) signaling of muscle contraction and relaxation
FKBP12 binding to RyR1 (zeige RYR1 ELISA Kits) enhances the gain of skeletal muscle excitation-contraction coupling
Data indicate that S107 increased FKBP12 binding to RyR1 (zeige RYR1 ELISA Kits) in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12.
A mutant with substitution at the sole cysteine residue of FKBP-12 (C23S) did not form dimers or trimers.
phosphorylation and K201 acted similarly to change the conformation of RyR1/2 and regulate FKBP12/12.6 binding.
expression higher in the silk gland and gut (zeige GUSB ELISA Kits)
A cDNA encoding the 12 kDa FKBP gene orthologue (FKBP12) in Bombyx mori was been isolated from both Bm-5 cultured cells and silk-gland tissue.
Specifically tested on two model systems, the power of iSPOT is demonstrated to accurately predict the structures of a large protein-protein complex (TGFbeta (zeige TGFB1 ELISA Kits)-FKBP12) and a multidomain nuclear receptor homodimer (HNF-4alpha (zeige HNF4A ELISA Kits)), based on the structures of individual components of the complexes.
These results identify a novel function for FKBP12 in downregulating MDM2 (zeige MDM2 ELISA Kits), which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.
Data show that FKBP12 (FK506 binding protein 1A)conformational transition Is coupled to histidine tautomerization.
Electrostatic effects on the folding stability of FKBP12
Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12.
RyRs have been identified as important targets of FKBP12 and FKBP12.6 (zeige FKBP1B ELISA Kits), members of the immunophilin family
How phosphorylation of RyR (zeige RYR1 ELISA Kits) affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6 (zeige FKBP1B ELISA Kits)) are involved in heart failure
Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11betaHSD1.
Selectivity within the FKBP (zeige FKBP7 ELISA Kits) family, in particular selective inhibition of FKBP12 or FKBP51 (zeige FKBP4 ELISA Kits), is possible. FKBP51 (zeige FKBP4 ELISA Kits) is a pharmacologically tractable target for stress-related disorders.
peptidyl prolyl cis-trans isomerase activity of FKBP12 probably plays a role in inhibition of receptor phosphorylation.
Stoichiometry of binding sites and FKBP (zeige FKBP7 ELISA Kits) exchange binding.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
12 kDa FK506-binding protein
, 12 kDa FKBP
, FK506 Binding Protein12-T1
, FK506 binding protein12
, FK506 binding protein12-T2
, FK506-binding protein 1A
, PPIase FKBP1A
, immunophilin FKBP12
, peptidyl-prolyl cis-trans isomerase FKBP1A
, Immunophilin FKBP12
, binding protein
, FK506-binding protein
, FK506-binding protein 1
, FK506-binding protein 12
, FK506-binding protein 1A (12kD)
, FK506-binding protein, T-cell, 12-kD
, calstabin 1
, protein kinase C inhibitor 2
, FK506 binding protein 2 (13 kDa)
, FK506-binding protein 1 (12kD)
, FK506-binding protein 1a
, FK506 binding protein 1A, 12kDa
, fk506-binding protein
, FK506-binding protein-like
, FK 506-binding protein