anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antikörper

Bezeichnung:
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antikörper (PKD1)
Auf www.antikoerper-online.de finden Sie aktuell 59 Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Polycystic Kidney Disease 1 (Autosomal Dominant) Kits (7) und Polycystic Kidney Disease 1 (Autosomal Dominant) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 72 Polycystic Kidney Disease 1 (Autosomal Dominant) Produkte verfügbar.
Synonyme:
mFLJ00285, PBP, Pc-1, PC1, Pkcm, PKD, PKD1, Prkcm, TRPP1

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Am meisten referenzierte anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antikörper

  1. Human Polyclonal PKD1 Primary Antibody für IF (p), IHC (p) - ABIN678083 : Chiou, Sang, Cheng, Ho, Wang, Pan: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. in Carcinogenesis 2013 (PubMed)
    Zeige alle 3 Referenzen für 678083

Weitere Antikörper gegen Polycystic Kidney Disease 1 (Autosomal Dominant) Interaktionspartner

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Interaktionspartner

  1. A novel mutation of the PKD1 gene has been identified with autosomal dominant polycystic kidney disease in an affected Chinese family.

  2. Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1-T, PKD1-NT and PKD2 (zeige PKD2 Antikörper) mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.

  3. this study shows that diet-induced obesity links to estrogen receptor (zeige ESR1 Antikörper)-positive breast cancer progression via LPA (zeige APOA Antikörper)/PKD-1-CD36 (zeige CD36 Antikörper) signaling-mediated microvascular remodeling

  4. Isolated polycystic liver disease genes define effectors of polycystin-1 function

  5. mechanical load upregulates expression of Runx2 (zeige RUNX2 Antikörper) gene via potentiation of PC1 (zeige PCSK1 Antikörper)-JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  6. Gly972Arg of PC-1 (zeige PCSK1 Antikörper) polymorphisms are associated with polycystic ovary syndrome.

  7. cortactin (zeige CTTN Antikörper) binds to E-cadherin (zeige CDH1 Antikörper), and that a posttranslational modification of cortactin (zeige CTTN Antikörper), RhoA (zeige RHOA Antikörper)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (zeige PRKD1 Antikörper)) at S298, impairs adherens junction assembly and supports their dissolution.

  8. Ten novel mutations in PKD1 gene were identified in 15 Chinese families with polycystic kidney disease.

  9. PKD1 mutations are associated with autosomal dominant polycystic kidney disease.

  10. The novel PKD1 c.8791+1_8791+5delGTGCG mutation has created a new splice site.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Interaktionspartner

  1. critical functions of PC1 (zeige PCSK1 Antikörper) are regulated by its ability to sense cytosolic calcium levels via binding to calmodulin (zeige Calm2 Antikörper)

  2. cortactin (zeige CTTN Antikörper) binds to E-cadherin (zeige CDH1 Antikörper), and that a posttranslational modification of cortactin (zeige CTTN Antikörper), RhoA (zeige RHOA Antikörper)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (zeige PRKD1 Antikörper)) at S298, impairs adherens junction assembly and supports their dissolution.

  3. Galpha12 (zeige GNA12 Antikörper) is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.

  4. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  5. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7 (zeige HDAC7 Antikörper), where it interacts with forkhead box protein O1 (zeige FOXO1 Antikörper) to suppress endothelial CD36 (zeige CD36 Antikörper) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  6. kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.

  7. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  8. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (zeige DGKA Antikörper) effect on MVB secretory traffic.

  9. detected a marked increase in the localization of beta-catenin (zeige CTNNB1 Antikörper) in the nucleus of crypt epithelial cells in the ileum of PKD1

  10. PKD1 phosphorylates AMPKalpha2 (zeige PRKAA2 Antikörper) at Ser485/491, thus diminishing AMPK (zeige PRKAA1 Antikörper) activity.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Alternative names and synonyms associated with Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1)

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) Antikörper
  • polycystic kidney disease 1 homolog (Pkd1) Antikörper
  • polycystic kidney disease 1 homolog (human) (Pkd1) Antikörper
  • protein kinase D1 (Prkd1) Antikörper
  • mFLJ00285 Antikörper
  • PBP Antikörper
  • Pc-1 Antikörper
  • PC1 Antikörper
  • Pkcm Antikörper
  • PKD Antikörper
  • PKD1 Antikörper
  • Prkcm Antikörper
  • TRPP1 Antikörper

Bezeichner auf Proteinebene für PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPEZIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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