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Human Polyclonal ABCD3 Primary Antibody für IHC (p), IHC - ABIN451658
Panov, Kubalik, Zinchenko, Ridings, Radoff, Hemendinger, Brooks, Bonkovsky: Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology. in American journal of physiology. Regulatory, integrative and comparative physiology 2011
Show all 2 Pubmed References
Human Monoclonal ABCD3 Primary Antibody für ICC, IF - ABIN4346500
Schrul, Kopito: Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains. in Nature cell biology 2016
Human Polyclonal ABCD3 Primary Antibody für ICC, IF - ABIN4346502
Reams, Jones-Triche, Chan, Hernandez, Soliman, Yates: Immunohistological analysis of ABCD3 expression in Caucasian and African American prostate tumors. in BioMed research international 2015
ABCD1 (zeige ABCD1 Antikörper) and ABCD2 (zeige Abcd2 Antikörper) are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 is involved in the transport of branched chain acyl-CoA (zeige GNPAT Antikörper) into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 (zeige NDUFB3 Antikörper) from lysosomes into the cytosol.
Data show that ACBD3 (zeige Acbd3 Antikörper) can recruit PI4KB (zeige PI4KB Antikörper) to model membranes as well as redirect PI4KB (zeige PI4KB Antikörper) to cellular membranes where it is not naturally found. Also, results show that ACBD3 (zeige Acbd3 Antikörper) regulates the enzymatic activity of PI4KB (zeige PI4KB Antikörper) kinase through membrane recruitment rather than allostery.
The N-terminal motif of PMP70 suppresses cotranslational targeting to the endoplasmic reticulum.
Increased ABCD3 expression correlates with Gleason Score.
Deficiency of peroxisomal ABCD3 resulted in bile acid biosynthesis defect.
We postulate a role for human ABCD3 in the oxidation of dicarboxylic acids and a role in buffering fatty acids that are overflowing from the mitochondrial beta-oxidation system
investigation of organelle-targeting properties of N-terminal portions of peroxisomal PMP70; amino acid sequence and domain structure of human form discussed
Pex19p binds to PMP70 co-translationally and keeps PMP70 in a proper conformation for the localization to peroxisome.
Testosterone metabolites did not alter expression of ABCD3 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.
MP70 (zeige GJA8 Antikörper) interacts with PEX19 (zeige PEX19 Antikörper) splice variants PEX19 (zeige PEX19 Antikörper)-delta-E2 and PEX19p-delta-E8.
Abcd3-/- mice accumulated the branched chain fatty acid phytanic acid after phytol loading.
investigation of organelle-targeting properties of N-terminal portions of peroxisomal PMP70; mouse full-length sequence & deletion sequences used as probes for intracellular targeting in COS cells
reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress in amyotrophic lateral sclerosis
PPARalpha (zeige PPARA Antikörper) up-regulates the expression of Abcd3 in small intestine.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
70 kDa peroxisomal membrane protein
, ATP-binding cassette sub-family D member 3
, Peroxisomal membrane protein-1 (70kD)
, dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))
, peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
, 68 kDa peroxisomal membrane protein
, peroxisomal membrane protein 1
, peroxisomal membrane protein, 70 kDa
, ATP-binding cassette, sub-family D, member 3
, ATP-binding cassette, sub-family D (ALD), member 3
, 70-kDa peroxisomal membrane protein
, Peroxisomal membrane protein 1
, ATP-binding cassette, sub-family D, member 3-like
, ATP-binding cassette sub-family D member 3-like