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Increased post-translational modification of proteins by SUMO-2/3 is a cytoprotective response against cell stress induced by ischaemia and reperfusion.
Sumoylation of PML (zeige PML ELISA Kits) with SUMO2 by UBC9/UBE2I (zeige UBE2I ELISA Kits) can lead to formation of polymeric SUMO chains. Data suggest that coordination of growing poly-SUMO chain with "back side" binding site on UBC9/UBE2I (zeige UBE2I ELISA Kits) appears to be required for SUMO chain elongation on PML (zeige PML ELISA Kits). (PML (zeige PML ELISA Kits) = promyelocytic leukemia protein (zeige PML ELISA Kits); SUMO2 = small ubiquitin-like modifier 2; UBC9/UBE2I (zeige UBE2I ELISA Kits) = ubiquitin-conjugating enzyme (zeige Ube2t ELISA Kits) UBC9/UBE2I (zeige UBE2I ELISA Kits))
The data demonstrate that SUMO2 conjugation and SENP3 (zeige ULP1 ELISA Kits)-driven deSUMOylation of PELP1 (zeige PELP1 ELISA Kits) is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation.
Data suggest that PIASy (zeige PIAS4 ELISA Kits) exhibits a SIM (zeige SIM2 ELISA Kits) (SUMO-interacting motif) in addition to the SIM (zeige SIM2 ELISA Kits) identified in homologous proteins in other species; both SIMs are located near C terminus of PIASy (zeige PIAS4 ELISA Kits), and both are required for full ligase activity of PIASy (zeige PIAS4 ELISA Kits); hydrophobic core residues of the new SIM (zeige SIM2 ELISA Kits) are essential in binding to SUMO-3 (zeige SUMO3 ELISA Kits). (PIASy (zeige PIAS4 ELISA Kits) = protein inhibitors of activated STAT (zeige STAT1 ELISA Kits) y; SUMO-3 (zeige SUMO3 ELISA Kits) = small ubiquitin-like modifier 3 (zeige SUMO3 ELISA Kits))
This study reveals an essential role of SUMOylated FADD (zeige FADD ELISA Kits) in Drp1 (zeige CRMP1 ELISA Kits)- and caspase-10 (zeige CASP10 ELISA Kits)-dependent necrosis.
The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1gamma sumoylation and poly-SUMO chain elongation.
This study demonstrated that two polymorphisms of SUMO2 were significantly associated with an increased risk of AD in female group.
FOXP2 (zeige FOXP2 ELISA Kits) can be modified with all three human SUMO proteins and that PIAS1 (zeige PIAS1 ELISA Kits) promotes this process.
Hsp27-Ubc9 pathway recognizes the conformation of mutant CFTR which leads to its SUMO-2 conjugation and degradation by the ubiquitin-proteasome system.
Data suggest that RAP80 (zeige UIMC1 ELISA Kits) SIM (zeige SIM2 ELISA Kits) (SUMO interacting motif) binds SUMO-2; both specificity and affinity are enhanced through phosphorylation of canonical CK2 (zeige CSNK2A1 ELISA Kits) (casein kinase 2) site within the SIM (zeige SIM2 ELISA Kits).
cyclin E (zeige CCNE1 ELISA Kits) is dynamically and highly conjugated to SUMO2/3 on chromatin, independently of Cdk2 (zeige CDK2 ELISA Kits) activity and origin activation.
we provide evidence for the existence of a preferential conjugation of AtSUMO1/2 compared with AtSUMO3/5, which is determined by a role of the E1-activating enzyme in SUMO paralogue discrimination.
SUM3 (zeige SUMO3 ELISA Kits) promotes plant defense downstream of salicylic acid, while SUM1 (zeige SUMO1 ELISA Kits) and SUM2 together prevent salicylic acid accumulation in noninfected plants.
SIZ1-mediated conjugation of SUMO1 (zeige SUMO1 ELISA Kits) and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
SUMO-2 inhibits aggregation of CPEB3 (zeige CPEB3 ELISA Kits).
The present study used immunohistochemical and immunoblot analysis with the different developmental stages of mice and demonstrated the developmentally regulated distribution of SUMO2/3 in the brain.
SUMO-2-Tg mouse lines exhibited cardiomyopathy with various severities. SUMO-2 directly regulated apoptosis by at least partially targeting calpain 2 (zeige CAPN2 ELISA Kits) and calpastatin (zeige CAST ELISA Kits).
Results indicate that a functional SUMO1 (zeige SUMO1 ELISA Kits)-3 expression is essential for emotionality and cognition
Expression levels and not functional differences between SUMO2 and SUMO3 (zeige SUMO3 ELISA Kits) are critical for normal embryogenesis.
Stress-induced phosphorylation of Thr486 in c-Myb (zeige MYB ELISA Kits) by p38 (zeige CRK ELISA Kits) mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.
post-ischemic activation of SUMO2/3 conjugation may define the fate of neurons exposed to a transient interruption of blood supply
Alterations in SUMO substrate conjugation may occur and global posttranslational modifications by ubiquitin may play an important role in the mechanisms underlying Alzheimer disease.
activation of SUMO2/3 conjugation is an endogenous neuroprotective stress response.
These results indicate that the functional role of SUMO-2/3 in the regulation of NFkappaB activity was conserved during evolution.
SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
, small ubiquitin-related modifier 2
, SMT3 homolog 2
, SMT3 suppressor of mif two 3 homolog 2
, sentrin 2
, ubiquitin-like protein SMT3A
, ubiquitin-like protein SMT3B
, small ubiquitin-related modifier 2-B
, SMT3 homolog 1
, SMT3 suppressor of mif two 3 homolog 1
, SMT3 suppressor of mif two 3 homolog 3
, small ubiquitin-related modifier 3
, MIF2 suppressor
, SMT3 supressor of mif two 3 homolog 2