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Studies indicate that the transcriptional co-activators YAP and TAZ (zeige TAZ ELISA Kits) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (zeige MMRN1 ELISA Kits)) elasticity and cell shape.
Data establish a molecular mechanism and functional significance of the hexosamine biosynthesis pathway in directly linking extracellular glucose signal to the Hippo-YAP pathway and tumorigenesis.
YAP1 immunohistochemical expression was sharply downregulated in medullary thyroid cancer
YAP1 exerted its effect on the chondrocyte differentiation by activating the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway
This report describes a novel mutation in YAP1 associated with isolated ocular coloboma in a family with an autosomal dominant pattern of inheritance with apparent incomplete penetrance.
The altered mRNA isoform, called MAGI3 (zeige MAGI3 ELISA Kits)(pPA (zeige PPA1 ELISA Kits)), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 (zeige MAGI3 ELISA Kits) from interacting with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation of human mammary epithelial cells.
Data suggest that high expression of phosphorylated mTOR (zeige FRAP1 ELISA Kits) (p-mTORS2448) and YAP1 correlates with poor prognosis of glioma patients; potential interaction between mTOR (zeige FRAP1 ELISA Kits) and YAP1 signaling pathways may participate in development/progression of gliomas. (mTOR (zeige FRAP1 ELISA Kits) = rapamycin and FKBP12 target 1 protein (zeige FRAP1 ELISA Kits); YAP1 = Yes-associated protein 1)
Decreased AMOT (zeige AMOT ELISA Kits)-p130 (zeige RBL2 ELISA Kits) expression coupled with high nuclear YAP1 expression resulted in shorter overall survival and disease-free survival in patients with advanced gastric cancer.
High Yap expression is associated with breast cancer.
High YAP1 expression is associated with pancreatic cancer.
Dystrophin-glycoprotein complex component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in mice
P38 MAPK (zeige MAPK14 ELISA Kits)-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration.
Nuclear YAP does not play a significant physiological role during oocyte development in mammals.
identify the mesenchymal requirement of YAP/TAZ (zeige TAZ ELISA Kits) in the gastrointestinal tract and highlight the functional interplays between Hippo and Hedgehog (zeige SHH ELISA Kits) signaling underlying temporal and spatial control of tissue growth and specification in developing gut (zeige GUSB ELISA Kits)
findings indicate that HIF-2alpha (zeige EPAS1 ELISA Kits) increases cancer cell growth by up-regulating YAP1 activity
found that epidermal YAP activity drives GLI2 (zeige GLI2 ELISA Kits) nuclear accumulation in the skin of YAP2-5SA-DeltaC mice, which depends on epidermal beta-catenin (zeige CTNNB1 ELISA Kits) activation
Yap and Taz (zeige TAZ ELISA Kits) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (zeige ITK ELISA Kits)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This study identifies YAP/TAZ as central mediators of VEGF signaling
These results suggest that YAP promotes muscle differentiation by activating the Abl (zeige ABL1 ELISA Kits)/Src (zeige SRC ELISA Kits)/MEKK3 (zeige MAP3K3 ELISA Kits)/MEK5 (zeige MAP2K5 ELISA Kits)/ERK5 (zeige MAPK7 ELISA Kits) kinase cascade.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (zeige AMOTL2 ELISA Kits) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) effector Lef1 (zeige LEF1 ELISA Kits).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (zeige TAZ ELISA Kits)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (zeige TAZ ELISA Kits) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa