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Pin1 (zeige PIN1 Proteine) enhances adipocyte differentiation by regulating the function of PPARgamma.
The authors report that macrophage PPARgamma deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 (zeige GPR132 Proteine) as a novel direct PPARgamma target in macrophage whose expression is enhanced by PPARgamma loss but repressed by PPARgamma activation.
Data indicate that obesity-induced insulin (zeige INS Proteine) resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5 (zeige STAT5A Proteine)-PPAR gamma pathway in vivo and in vitro.
TAK1 (zeige NR2C2 Proteine) is required for PPARgamma transactivation and promotes PPARgamma transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (zeige TAB1 Proteine)).
PPAR gamma role in fat deposition and body weight gain.PPAR gamma is regulated by miR (zeige MLXIP Proteine)-27b.
These findings demonstrated that apigenin could prevent the D-GalN (zeige GAL Proteine)/LPS (zeige TLR4 Proteine)-induced liver injury in mice, and its mechanisms might be associated with the increments of Nrf-2 (zeige NFE2L2 Proteine)-mediated antioxidative enzymes and modulation of PPARgamma/NF-kappaB (zeige NFKB1 Proteine)-mediated inflammation.
Time course analysis demonstrated that the adipogenic 'hub', sampled by PPARgamma and Lpin1 (zeige LPIN1 Proteine), undergoes orchestrated reorganization during adipogenesis.
Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha (zeige PPARA Proteine) and peroxisome proliferator-activated receptor-gamma.
IRF6 (zeige IRF6 Proteine) suppresses PPARgamma through binding IRF (zeige TRIM63 Proteine) recognition sites located upstream of the PPARgamma coding region. Taken together, the results suggest that an IRF6 (zeige IRF6 Proteine)/PPARgamma regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.
NFIA (zeige NFIA Proteine) activates the cell-type-specific enhancers and facilitates the binding of PPARgamma to control the brown fat gene program.
Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma)/retinoid X receptor alpha (RXRalpha (zeige RXRA Proteine)) that inhibits expression/secretion of inflammatory cytokines.
Results show that resistin (zeige RETN Proteine) down-regulates the transcription of GLUT1 (zeige SLC2A1 Proteine) by suppressing the expression of PPARG, thus causing impaired glucose transportation in endothelial cell layers.
these studies demonstrate that PPARgamma is an important modulator of MUC16 (zeige MUC16 Proteine) expression.
a panel of proteins correlated with PPARgamma expression that could be associated with colorectal cancer, was identified.
We propose a novel role of the miR (zeige MLXIP Proteine)-27a/PPARgamma/beta-catenin (zeige CTNNB1 Proteine) axis in fostering the progression toward more deteriorated podocyte injury in diabetic nephropathy (DN). Targeting miR (zeige MLXIP Proteine)-27a could be a potential therapeutic approach for DN.
the presented cPCA mapping of the PPARg-ligand complexes may guide in silico drug discovery programs seeking to avoid stabilization of helix 12 in their development of partial- and non-agonistic PPARg ligands.
The presence of the PPARgamma (Pro12Ala) SNP did not modify the association between inorganic arsenic methylation capacity and breast cancer.
COX-2 is a potential marker for identifying high-risk sebaceous gland carcinoma (SGC (zeige SGCB Proteine)) patients. Expression of PPAR-gamma in eyelid SGC (zeige SGCB Proteine) cases reflects terminal sebaceous differentiation.
PAK4 (zeige PAK4 Proteine) downregulation decreased PPARgamma-mediated Nox1 (zeige NOX1 Proteine) expression and suppressed EMT (zeige ITK Proteine) in IR-treated glioma cells.
The results suggest the higher expression of miR (zeige MYLIP Proteine)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (zeige FRAP1 Proteine) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (zeige MYLIP Proteine)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (zeige MYLIP Proteine)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (zeige MYOD1 Proteine) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (zeige RETN Proteine) and PPARgamma expression in the porcine ovary. Resistin (zeige RETN Proteine) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (zeige RETN Proteine) expression; thus, PPARgamma is a new key regulator of resistin (zeige RETN Proteine) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (zeige MSTN Proteine) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (zeige MYOD1 Proteine) expression.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Proteine)) gene expression and increased adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Proteine) regulation pattern for PPARgamma to that of ATGL (zeige PNPLA2 Proteine) in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (zeige NFKB1 Proteine) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (zeige CEBPB Proteine) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (zeige FFAR2 Proteine) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG and SP1 (zeige SP1 Proteine) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (zeige PTPN2 Proteine), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (zeige PPARA Proteine)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (zeige MMP1 Proteine) and increasing PPARg, GSTa (zeige GSTa2 Proteine), and ABCA1 (zeige ABCA1 Proteine) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (zeige PTGS2 Proteine) down-regulation and 3beta-HSD (zeige HAL Proteine) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (zeige MMP3 Proteine) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (zeige LEP Proteine) and up-regulates PPARgamma and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (zeige PIK3CA Proteine), Akt (zeige AKT1 Proteine), and eNOS (zeige NOS3 Proteine) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma