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Rat (Rattus) MAPT ELISA Kit für Sandwich ELISA - ABIN416529
Ekici, Uysal, Cikriklar, Özbek, Turgut Cosan, Baydemir, Kazanci, Hafizo?lu: Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury. in European review for medical and pharmacological sciences 2014
Human MAPT ELISA Kit für Sandwich ELISA - ABIN415122
Lasek-Bal, Jedrzejowska-Szypulka, Rozycka, Bal, Kowalczyk, Holecki, Dulawa, Lewin-Kowalik: The presence of Tau protein in blood as a potential prognostic factor in stroke patients. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2016
the tau isoforms with exon-2 and exon-10 segments increase in CSF (zeige CSF2 ELISA Kits) of sporadic Creutzfeldt-Jakob disease and some types of genetic Creutzfeldt-Jakob disease.
Tau protein, along with amyloidBeta42 and GFAP (zeige GFAP ELISA Kits), were increased in plasma up to 90 days after traumatic brain injury compared with controls.
Regions other than the constitutive promoter may be involved in microtubule-associated protein tau gene regulation in tauopathies.
LRRK2 (zeige LRRK2 ELISA Kits) regulates intracellular Tau levels, contributing to the progression of the pathology caused by the LRRK2 (zeige LRRK2 ELISA Kits)-mediated proteasome impairment.
Insulin (zeige INS ELISA Kits) is accumulated and retained as oligomers in hyperphosphorylated tau-bearing neurons in Alzheimer's disease and in several of the most prevalent human tauopathies.
Inhibition of CaN attenuated the hTau-induced CREB (zeige CREB1 ELISA Kits) dephosphorylation with improved synapse and memory functions.
Study describes a protocol to extract and measure tau seeding activity from small volumes (.04 mm(3)) of formaldehyde-fixed tissue immediately adjacent to that used for immunohistochemistry, validated this method with the PS19 transgenic mouse model, and easily observed seeding well before the development of phospho-tau pathology. Also accurately isolated two tau strains, DS9 and DS10, from fixed brain tissues in mice.
evidence that JNK (zeige MAPK8 ELISA Kits) signaling pathway is an upstream regulator of hyperosmotic stress-induced Tau cleavage and apoptosis in SH-SY5Y through the control of caspase-3 (zeige CASP3 ELISA Kits) activation.
Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was characterized extensively in human plasma, including by single molecule array technology with 303 subjects. In human plasma, tau was explicitly identified within L1CAM exoso (zeige L1CAM ELISA Kits)mes. In contrast to Alzheimer's patients, L1CAM exosomal tau was significantly higher in Parkinson's patients than controls and correlated with cerebrospinal fluid tau.
Our findings unmask tau-mediated perturbations of specific pathways associated with neuronal vulnerability, revealing potential early disease biomarkers and therapeutic targets for FTD (zeige FTL ELISA Kits) and other tauopathies.
Csnk1e (zeige CSNK1E ELISA Kits) deletion increased mu opioid receptor (zeige OPRM1 ELISA Kits)-dependent behaviors.
Study demonstrates a mechanistic link between brain Abeta (zeige APP ELISA Kits) deposition and CSF (zeige CSF2 ELISA Kits) tau, and thus, CSF (zeige CSF2 ELISA Kits) tau may present an important readout of Abeta (zeige APP ELISA Kits) deposition in mouse models and likely in Alzheimer's disease.
Tau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. The efflux of Tau, including a fraction via CNS-derived L1CAM (zeige L1CAM ELISA Kits) exosomes, was observed in mice. Tau is readily transported from the brain to the blood.
Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn (zeige FYN ELISA Kits)-mediated local protein translation.
The authors concluded that the FcgammaRIIb-SHIP2 (zeige INPPL1 ELISA Kits) axis links Abeta (zeige APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
Pin1 (zeige PIN1 ELISA Kits) serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Here, the authors identify another Wnt (zeige WNT2 ELISA Kits) signaling amplifier, CKIepsilon (zeige CSNK1E ELISA Kits), which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta (zeige CSNK1D ELISA Kits).
PGRN (zeige GRN ELISA Kits) decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B ELISA Kits)-contaning NMDA receptors
These results suggest that tau haploinsufficiency, without the compensation effect of MAP1A (zeige MAP1A ELISA Kits), induces reduction of Otx2 (zeige OTX2 ELISA Kits) expression, increases prenatal cell death, and accordingly leads to selective loss of VTA DA neurons in the early postnatal stage.
High-glucose induces tau hyperphosphorylation through activation of TLR9 (zeige TLR9 ELISA Kits)-P38 MAPK (zeige MAPK14 ELISA Kits) pathway.
Findings suggest that the endothelin-1 (zeige EDN1 ELISA Kits)-induced down-regulation of NaV1.7 (SCN9A (zeige SCN9A ELISA Kits)) diminishes NaV1.7 (zeige SCN9A ELISA Kits)-related catecholamine secretion and dephosphorylation of tau.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (zeige FYN ELISA Kits).
show that cathepsin D (zeige CTSD ELISA Kits) cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP (zeige APP ELISA Kits) are involved in the pathogenesis of Alzheimer's disease
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
We conclude that GSK3beta (zeige GSK3b ELISA Kits) phosphorylates tau directly at S(202) but requires the previous phosphorylation on S(235) to phosphorylate T(231). Phosphorylation of S(396), on the other hand, occurs sequentially.
Suppressing the expression of all tau isoforms disrupted only those neuronal microtubules containing class II beta-tubulin (zeige TUBB ELISA Kits), and that boosting the expression of the largest 'big', but not the smallest, tau isoform enhanced neurite outgrowth.
We found that inversion of the MAPT region is similarly polymorphic in other great ape (zeige CCDC88A ELISA Kits) species, and we present evidence that the inversions occurred independently in chimpanzees and humans
age-related increase in cAMP-dependent protein kinase (zeige CDK7 ELISA Kits) (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2 (zeige CA2 ELISA Kits)+)-storing spine apparatus.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
G protein beta1/gamma2 subunit-interacting factor 1
, neurofibrillary tangle protein
, paired helical filament-tau
, CKI, epsilon
, KC1 epsilon
, casein kinase I isoform epsilon
, Tau microtubule-associated protein
, microtubule associated protein tau
, tau-like protein
, tau-like protein-2
, microtubule-associated protein tau
, Microtubule-associated protein tau
, Neurofibrillary tangle protein
, Paired helical filament-tau
, sodium- and chloride-dependent taurine transporter
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6
, solute carrier family 6 (neurotransmitter transporter, taurine), member 6b
, taurine transporter