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Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis.
Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
These findings suggest that coronin 1A (zeige CORO1A Proteine) modulates endothelial cell apoptosis by regulating p38beta expression and activation.
The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder.
p38beta is a novel regulatory target of the transcription factor Pokemon (zeige ZBTB7A Proteine) and positively regulated by Pokemon (zeige ZBTB7A Proteine) in hepatic cells.
Data show that the p38 MAPK (p38 (zeige MAPK14 Proteine)) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell.
Differential roles for p38alpha (zeige MAPK14 Proteine) and p38beta in the HGF (zeige HGF Proteine)-induced expression of key osteogenic markers.
study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells
Study identifies Hsp27 (zeige HSPB1 Proteine) as a novel target of ILK (zeige ILK Proteine)-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
propose that active p38-Mapk14 (zeige MAPK14 Proteine)/11 act as enablers, and Erk1/2 as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Double deficiency of p38alpha (zeige MAPK14 Proteine) and p38beta in naive CD4 (zeige CD4 Proteine)(+) T cells resulted in an attenuation of MAPK (zeige MAPK1 Proteine)-activated protein kinase (zeige CDK7 Proteine) (MK)-dependent mTOR (zeige FRAP1 Proteine) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Data indicate that alternatively activated p38alpha (zeige MAPK14 Proteine) and p38beta up-regulates the transcription factors NFATc1 (zeige NFATC1 Proteine) and IRF4 (zeige IRF4 Proteine).
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha (zeige MAPK14 Proteine)/beta MAPK (zeige MAPK1 Proteine) activity
work reveals a 'seed and soil' mechanism where TGF-beta2 (zeige TGFB2 Proteine) and TGF-beta (zeige TGFB1 Proteine)-RIII signalling through p38alpha (zeige MAPK14 Proteine)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Results suggest that UBR2 (zeige UBR2 Proteine) up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta (zeige CEBPB Proteine) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
inhibition of the SOCE downstream target CaM kinase kinase beta (zeige CAMKK2 Proteine) (CaMKKbeta) or knockdown of AMPKalpha1 (zeige PRKAA1 Proteine) suppressed PAR-1 (zeige MARK2 Proteine)-mediated phosphorylation of p38beta and hence STIM1 (zeige STIM1 Proteine).
p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB) phosphorylation mediated by p38beta and p38delta.
p38beta MAPK (zeige MAPK1 Proteine) is dispensable in the brain in regards to proinflammatory cytokine production and neurotoxicity induced by LPS (zeige TLR4 Proteine) inflammatory insult
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
mitogen-activated protein kinase 11
, mitogen-activated protein kinase 11-like
, MAP kinase 11
, MAP kinase p38 beta
, MAPK 11
, mitogen-activated protein kinase p38 beta
, mitogen-activated protein kinase p38-2
, stress-activated protein kinase 2
, stress-activated protein kinase 2b
, stress-activated protein kinase-2
, stress-activated protein kinase-2b
, mitogen activated protein kinase 11
, protein kinase, mitogen activated kinase, 11, p38beta