anti-Hund Cortactin Antikörper für Immunohistochemistry (Formalin-fixed Sections)

Recommended Cortactin Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cortactin (CTTN) Antikörper
  • Cttn
  • CTTN
  • cttn
  • ems1
  • CG3637
  • Dmel\CG3637
  • cortactin
  • 1110020L01Rik
  • Ems1
  • CTTN1
  • P85.25
  • EMS1
  • Cttnb
  • cortactin
  • cortactin S homeolog
  • hematopoietic cell-specific Lyn substrate 1
  • src substrate cortactin
  • Src substrate cortactin
  • CG3637 gene product from transcript CG3637-RD
  • cortactin L homeolog
  • CTTN
  • cttn.S
  • hcls1
  • CpipJ_CPIJ006351
  • Bm1_57220
  • cttn
  • LOC100533277
  • Cortactin
  • Cttn
  • cttn.L
Reaktivität
Hund, Human
202
123
76
8
7
6
4
3
3
3
3
1
1
1
1
1
1
Wirt
Maus
179
31
19
Klonalität
Monoklonal
Konjugat
Dieser Cortactin Antikörper ist unkonjugiert
4
4
4
4
4
4
Applikation
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
206
100
90
40
22
17
13
5
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN967709
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN967710 IHC (f) IF IP WB Mouse IgG1 Anmelden zum Anzeigen 30-Cortactin 6

General

Antigen Cortactin (CTTN) Antikörper
Reaktivität Hund, Human
(202), (123), (76), (8), (7), (6), (4), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Wirt Maus
(179), (31), (19)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser Cortactin Antikörper ist unkonjugiert
(4), (4), (4), (4), (4), (4)
Applikation Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(206), (100), (90), (40), (22), (17), (13), (5), (3), (3), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-Cortactin Antikörper

Target Details Cortactin Anwendungsinformationen Handhabung Referenzen für anti-Cortactin Antikörper (ABIN967709) Bilder
Kreuzreaktivität Human, Hund
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Chicken Cortactin
Klon 30-Cortactin
Isotyp IgG1

Target Details Cortactin

Produktdetails anti-Cortactin Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Cortactin Antikörper (ABIN967709) Bilder zurück nach oben
Antigen
Andere Bezeichnung Cortactin (CTTN Antibody Abstract)
Hintergrund Cortactin is a protein which is represented by two structurally related isoforms of 80 kDa and 85 kDa. Sequence analysis of this protein reveals the presence of a carboxy-terminal SH3 domain, as well as six internal tandem repeats of a 37 amino acid sequence. It is able to bind to F-actin via this N-terminal repeat region, and colocalizes with actin in the cell. Cortactin was originally described as a protein that is tyrosine-phosphorylated in cells transformed by the src oncogene, in which it localizes to rosettes or podosomes. It has since been shown that other stimuli, such as bacterial invasion, treatment with growth factors, and integrin-mediated cell adhesion, are also capable of inducing phosphorylation of cortactin. Some additional evidence indicates that cortactin may actually be a substrate of syk, with src acting as an upstream signaling molecule. This antibody is routinely tested by western blot analysis.
Molekulargewicht 85/80 kDa
Forschungsgebiet Cancer, Cell Cycle, Cytoskeleton, Microfilaments
Pathways MAPK Signalweg

Anwendungsinformationen

Produktdetails anti-Cortactin Antikörper Target Details Cortactin Handhabung Referenzen für anti-Cortactin Antikörper (ABIN967709) Bilder zurück nach oben
Kommentare

Related Products: ABIN968533, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Cortactin Antikörper Target Details Cortactin Anwendungsinformationen Referenzen für anti-Cortactin Antikörper (ABIN967709) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20°C.

Referenzen für anti-Cortactin Antikörper (ABIN967709)

Produktdetails anti-Cortactin Antikörper Target Details Cortactin Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Lavoie, Champagne, Gingras, Robert: "Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases." in: The Journal of cell biology, Vol. 150, Issue 5, pp. 1037-56, 2000

Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, 1998

Dehio, Prévost, Sansonetti: "Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway." in: The EMBO journal, Vol. 14, Issue 11, pp. 2471-82, 1995

Wu, Parsons: "Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex." in: The Journal of cell biology, Vol. 120, Issue 6, pp. 1417-26, 1993

Wu, Reynolds, Kanner, Vines, Parsons: "Identification and characterization of a novel cytoskeleton-associated pp60src substrate." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5113-24, 1991

Bilder

Produktdetails anti-Cortactin Antikörper Target Details Cortactin Anwendungsinformationen Handhabung Referenzen für anti-Cortactin Antikörper (ABIN967709) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Cortactin (CTTN) antibody (ABIN967709) Western blot analysis of Cortactin on a A431 lysate. Lane 1: 1:1000, lane 2: 1:2000, ...
Immunofluorescence (IF) image for anti-Cortactin (CTTN) antibody (ABIN967709) Immunofluoresence staining of NIH-3T3 cells.