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Human Polyclonal KEAP1 Primary Antibody für IF (p), IHC (p) - ABIN702085
Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015
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Human Monoclonal KEAP1 Primary Antibody für FACS, IHC - ABIN1098141
Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011
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Human Monoclonal KEAP1 Primary Antibody für ICC, FACS - ABIN1098137
Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010
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Human Monoclonal KEAP1 Primary Antibody für FACS, IHC - ABIN2453954
Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014
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Cow (Bovine) Polyclonal KEAP1 Primary Antibody für IHC, WB - ABIN2775979
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
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Human Polyclonal KEAP1 Primary Antibody für ELISA, IHC - ABIN4328595
Dinkova-Kostova, Talalay, Sharkey, Zhang, Holtzclaw, Wang, David, Schiavoni, Finlayson, Mierke, Honda: An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. in The Journal of biological chemistry 2010
Human Monoclonal KEAP1 Primary Antibody für FACS, IHC - ABIN4328597
Licht-Mayer, Wimmer, Traffehn, Metz, Brück, Bauer, Bradl, Lassmann: Cell type-specific Nrf2 expression in multiple sclerosis lesions. in Acta neuropathologica 2015
Data suggest that Keap1, rather than Nrf2 (zeige GABPA Antikörper), is critical for the recruitment of iASPP (zeige PPP1R13L Antikörper) into the Keap1-Nrf2 (zeige GABPA Antikörper) complex
The modification of NRF2 (zeige GABPA Antikörper) or KEAP1 expression in non-small cell lung cancer cell lines disrupted downstream gene expression and cell sensitivity to platinum-based drugs.
These data demonstrate that the beneficial properties of SFN (zeige SFN Antikörper) extend beyond activation of the KEAP1-Nrf2 (zeige GABPA Antikörper)-ARE system and warrant further interrogation given the current use of this agent in multiple clinical trials
Result showed that there was a significant association between Keap1 and phosphorylated (p) Nrf2 (zeige GABPA Antikörper) expression in hepatocellular carcinoma. Higher pNrf2 expression was more likely observed in those specimens with reduced Keap1 expression.
Results provide evidence for a critical role of mutations in TP53 (zeige TP53 Antikörper) and KEAP1 during lung squamous cell carcinoma (LSCC oncogenesis, because deletion of either gene leads to increased self-renewal of airway basal stem cells. Also, KEAP1/NRF2 (zeige GABPA Antikörper) mutations increase radioresistance and predict local tumor recurrence in radiotherapy treated LSCC patients.
Study showed that Sequestosome 1 (zeige SQSTM1 Antikörper)-mediated sequestration of Keap1 is associated with chronic activation of the Nrf2 (zeige GABPA Antikörper) stress response pathway in the autophagic vacuolar myopathie muscle; demonstrated that Nrf2 (zeige GABPA Antikörper) signaling is upregulated in autophagic muscle disorders and raise the possibility that autophagy disruption in skeletal muscle leads to dysregulation of cellular redox homeostasis.
Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3 (zeige CUL3 Antikörper)-based E3 ubiquitin ligase (zeige MUL1 Antikörper). Keap1 regulates the activity of Nrf2 (zeige GABPA Antikörper) and acts as a sensor for oxidative and electrophilic stresses.
NRF2 (zeige GABPA Antikörper) is regulated at protein level by proteasomal degradation via KEAP1. Data suggest that antioxidant-induced up-regulation of NRF2 (zeige GABPA Antikörper) expression (a) overcomes KEAP1 regulation, (b) activates NRF2 (zeige GABPA Antikörper) translocation to nucleus, and (c) activates antioxidant response element. (NRF2 (zeige GABPA Antikörper) = nuclear factor [erythroid-derived 2]-like 2 protein; KEAP1 = Kelch-like ECH-associated protein 1)
Results indicate that microRNA miR (zeige MLXIP Antikörper)-141 targets kelch like ECH associated protein 1 (Keap1) to activate NF-E2-related factor 2 (Nrf2 (zeige NFE2L2 Antikörper)) signaling, which protects retinal pigment epithelium cells (RPEs) and retinal ganglion cells (RGCs) from UV radiation.
The authors show that O-GlcNAcylation of KEAP1 by OGT (zeige OGT Antikörper) at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (zeige GABPA Antikörper).
the potency of 15d-PGJ2 as a signalling molecule (zeige GDF5 Antikörper) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.
serine 351 phosphorylation of p62 (zeige GTF2H1 Antikörper) did not enhance its binding to Keap1 or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (zeige NFE2L2 Antikörper)) transcription factor in this neuronal context. Nrf2 (zeige NFE2L2 Antikörper) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (zeige NFE2L2 Antikörper) gene
These results suggest that the Keap1/Nrf2 (zeige NFE2L2 Antikörper) axis plays a critical role in NFATc1 (zeige NFATC1 Antikörper) expression and osteoclastogenic progression.
Results show that Keap1 deficiency in long-term hematopoietic stem cells increases the number of multipotent progenitor cells in steady-state hematopoiesis, and impairs their hematopoietic regeneration capacity .
During cellular stress or electrolytic imbalance, cysteine residue modification in Keap1 induces Nrf2 (zeige NFE2L2 Antikörper) release from the Nrf2 (zeige NFE2L2 Antikörper)-Keap1 complex, which stabilizes Nrf2 (zeige NFE2L2 Antikörper) and causes its nuclear translocation.
Results showed that in the basal state, the amount of Keap1 and Cul3 (zeige CUL3 Antikörper) proteins were maintained at higher levels than that of Nrf2 (zeige NFE2L2 Antikörper), and remained the same even under oxidative and electrophilic stimuli.
This study found that under oxidative stress induced (zeige SQSTM1 Antikörper) by experimental periodontitis, the Nrf2 (zeige NFE2L2 Antikörper)/antioxidant defense pathway was activated and could be visualized from the luciferase activity in the in Keap1-dependent oxidative stress detector-luciferase mice model.
Caffeic acid induces Nrf2 (zeige NFE2L2 Antikörper) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (zeige NFE2L2 Antikörper) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (zeige NFE2L2 Antikörper) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (zeige CTTN Antikörper) independently of its role in oxidant stress responses.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (zeige NFE2L2 Antikörper), indicating that the presence of either Cys (zeige DNAJC5 Antikörper)-273 or Cys (zeige DNAJC5 Antikörper)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (zeige NFE2L2 Antikörper) system comprises discrete sensor sites, including the Keap1 cysteines Cys (zeige DNAJC5 Antikörper)-151 and Cys (zeige DNAJC5 Antikörper)-273, for a variety of Nrf2 (zeige NFE2L2 Antikörper)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein