anti-Ratte (Rattus) Optineurin Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended Optineurin Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Optineurin (OPTN) Antikörper
  • nrp
  • fip2
  • hip7
  • hypl
  • glc1e
  • tfiiia-intp
  • ALS12
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • TFIIIA-INTP
  • Fip2
  • 4930441O07Rik
  • fj52f04
  • si:ch211-240l19.3
  • wu:fj52f04
  • zgc:66386
  • zgc:77868
  • optineurin
  • optineurin L homeolog
  • OPTN
  • optn
  • Optn
  • optn.L
Epitop
AA 115-130
11
10
9
8
7
6
6
4
4
4
3
2
2
2
1
1
1
Reaktivität
Human, Maus, Schwein, Ratte (Rattus)
90
41
22
10
7
7
6
5
5
2
2
2
2
1
1
Wirt
Kaninchen
89
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
72
26
23
20
13
13
7
6
2
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN5611418
$ 455.40
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1737662 IHC (p) WB Rabbit IgG AA 575-591 Anmelden zum Anzeigen Polyclonal
1 ABIN5554063 IHC (p) WB Rabbit AA 575-591 Anmelden zum Anzeigen Polyclonal
1 ABIN2451620 IHC (p) WB Rabbit IgG AA 575-591 Anmelden zum Anzeigen Polyclonal
1 ABIN2727923 EIA ICC IF IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal

General

Antigen Optineurin (OPTN) Antikörper
Epitop AA 115-130
(11), (10), (9), (8), (7), (6), (6), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Reaktivität Human, Maus, Schwein, Ratte (Rattus)
(90), (41), (22), (10), (7), (7), (6), (5), (5), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(89), (4)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(72), (26), (23), (20), (13), (13), (7), (6), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Sequenz KGKSERSSED PTDDSR
Spezifität This antibody recognizes Optineurin (OPTN).
Kreuzreaktivität (Details) Species reactivity (expected):Mouse, Porcine and Rat.
Species reactivity (tested):Human.
Reinigung Immunoaffinity Chromatography
Immunogen Synthetic peptide corresponding to amino acids 115-130 of Human Optineurin.
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Optineurin / HIP7 (OPTN Antibody Abstract)
Hintergrund Optineurin plays a neuroprotective role in the eye and optic nerve. Apoptosis is controlled by a variety of signalling mechanisms and is relevant to several diseases and normal development. Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as presented in a study of adenovirus proteins that prevent cytolysis after TNF? stimulation. Optineurin can be phosphorylated, however it is currently unknown what kinases achieve this or what other mammalian proteins interact with it downstream of TNF? or Fas signalling. Working at or near cell membranes and in concert with Rab8 and Huntingtin, optineurin has been implicated in membrane traffic regulation and cellular morphogenesis. The exact role of optineurin protein in apoptosis is currently unknown and interestingly optineurin gene mutations have been correlated with certain types of glaucoma. Increased apoptosis of trabecular meshwork cells is an identified factor for pathogenesis of glaucoma.Synonyms: E3-14.7K-interacting protein, FIP-2, FIP2, GLC1E, HYPL, Huntingtin yeast partner L, Huntingtin-interacting protein 7, Huntingtin-interacting protein L, NEMO-related protein, NRP, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein
Gen-ID 10133
NCBI Accession NP_001008212
UniProt Q96CV9
Pathways M Phase

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise Western blot. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Konzentration 0.6 mg/mL
Buffer TBS, pH 7.4 containing 50 % Glycerol, 0.5 mg/mL BSA as stabilizers and 0.02 % Sodium Azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
 image for anti-Optineurin (OPTN) (AA 115-130) antibody (ABIN5611418) anti-Optineurin (OPTN) (AA 115-130) antibody