anti-Ratte (Rattus) Optineurin Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Optineurin Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Optineurin (OPTN) Antikörper
  • nrp
  • fip2
  • hip7
  • hypl
  • glc1e
  • tfiiia-intp
  • ALS12
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • TFIIIA-INTP
  • Fip2
  • 4930441O07Rik
  • fj52f04
  • si:ch211-240l19.3
  • wu:fj52f04
  • zgc:66386
  • zgc:77868
  • optineurin
  • optineurin L homeolog
  • OPTN
  • optn
  • Optn
  • optn.L
Reaktivität
Human, Maus, Ratte (Rattus)
90
41
22
10
7
7
6
5
5
3
2
2
2
1
1
Wirt
Kaninchen
89
4
Klonalität
Polyklonal
Konjugat
Alexa Fluor 594
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
73
26
23
21
13
12
7
6
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Produktnummer ABIN2804890
$ 405.90
Zzgl. Versandkosten $45.00

General

Antigen Optineurin (OPTN) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(90), (41), (22), (10), (7), (7), (6), (5), (5), (3), (2), (2), (2), (1), (1)
Wirt Kaninchen
(89), (4)
Klonalität
Polyklonal
Konjugat Alexa Fluor 594
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(73), (26), (23), (21), (13), (12), (7), (6), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Optineurin
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Optineurin (OPTN Antibody Abstract)
Hintergrund

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Subcellular location: Cytoplasm

Synonyms: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP, Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, OPTN

Gen-ID 10133
UniProt Q96CV9
Forschungsgebiet Neurology, Innate Immunity, Cytokines
Pathways M Phase

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months