anti-Human Optineurin Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Optineurin Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Optineurin (OPTN) Antikörper
  • nrp
  • fip2
  • hip7
  • hypl
  • glc1e
  • tfiiia-intp
  • ALS12
  • FIP2
  • GLC1E
  • HIP7
  • HYPL
  • NRP
  • TFIIIA-INTP
  • Fip2
  • 4930441O07Rik
  • fj52f04
  • si:ch211-240l19.3
  • wu:fj52f04
  • zgc:66386
  • zgc:77868
  • optineurin
  • optineurin L homeolog
  • OPTN
  • optn
  • Optn
  • optn.L
Reaktivität
Human, Maus
90
41
23
10
7
7
6
5
5
3
2
2
2
1
1
Wirt
Kaninchen
89
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
73
26
23
20
13
12
7
6
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2178063
$ 306.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2178066 IF (p) Alexa Fluor 555 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178065 IF (p) Alexa Fluor 488 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178067 IF (p) Alexa Fluor 647 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178069 IF (p) Cy3 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178070 IF (p) Cy5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178064 IF (p) Alexa Fluor 350 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178073 IF (p) FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178071 IF (p) Cy5.5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2178072 IF (p) Cy7 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2804890 IF (p) Alexa Fluor 594 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN5008028 IF (p) Alexa Fluor 750 Rabbit IgG AA 350-400 Anmelden zum Anzeigen Polyclonal
1 ABIN5008027 IF (p) Alexa Fluor 680 Rabbit IgG AA 350-400 Anmelden zum Anzeigen Polyclonal

General

Antigen Optineurin (OPTN) Antikörper
Reaktivität Human, Maus
(90), (41), (23), (10), (7), (7), (6), (5), (5), (3), (2), (2), (2), (1), (1)
Wirt Kaninchen
(89), (4)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(73), (26), (23), (20), (13), (12), (7), (6), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Optineurin
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Optineurin (OPTN Antibody Abstract)
Hintergrund

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Subcellular location: Cytoplasm

Synonyms: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP, Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, OPTN

Gen-ID 10133
UniProt Q96CV9
Forschungsgebiet Neurology, Innate Immunity, Cytokines
Pathways M Phase

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Optineurin (OPTN) antibody (ABIN2178063) Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling i...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Optineurin (OPTN) antibody (ABIN2178063) Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling i...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Optineurin (OPTN) antibody (ABIN2178063) Paraformaldehyde-fixed, paraffin embedded mouse testis, Antigen retrieval by boiling ...
Western Blotting (WB) image for anti-Optineurin (OPTN) antibody (ABIN2178063) Lane 1: Mouse Cerebrum lysates; Lane 2: Mouse cerebellum; probed with Optineurin Poly...