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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491397
Bruno, Cuello: Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491392
Van Den Broeck, Stevenaert, Taveirne, Debacker, Vangestel, Vandekerckhove, Taghon, Matthys, Plum, Held, Dewerchin, Yokoyama, Leclercq: Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. in Blood 2008
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Human PLG Protein expressed in Human - ABIN491018
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
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Cow (Bovine) PLG Protein expressed in Bovine - ABIN491395
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
Horse (Equine) PLG Protein expressed in Horse - ABIN780187
Velineni, Timoney: Characterization and protective immunogenicity of the SzM protein of Streptococcus zooepidemicus NC78 from a clonal outbreak of equine respiratory disease. in Clinical and vaccine immunology : CVI 2013
Analysis of plasminogen genetic variants in multiple sclerosis patients has been reported.
Enolase of Mtb (zeige NCAPG2 Proteine) is present on its surface and binds human plasminogen with high affinity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator (zeige PLAT Proteine) and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin (zeige Alpha2 Antiplasmin Proteine) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
The mechanism for plasminogen/M protein binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management
t-PA (zeige PLAT Proteine) binds to Lys91 in the MBP (zeige MBL2 Proteine) NH2-terminal region and PLG binds to Lys122 in the MBP (zeige MBL2 Proteine) COOH-terminal region. This proximity promotes the activation of PLG by t-PA (zeige PLAT Proteine).
in the presence of platelet polyphosphate and the downstream substrate fibrin, alphaFXIIa is a highly efficient and favorable plasminogen activator.
Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer
Our findings indicate a new pathway for bradykinin formation in patients with HAE, in which FXII (zeige F12 Proteine) is cleaved and activated by plasmin.
VWF (zeige VWF Proteine) susceptibility to plasmin proteolysis at K1491-R1492 is modulated by local N-linked glycan expression within A1A2A3, and specifically inhibited by heparin binding to the A1 domain.
Plasminogen and P4HA2 (zeige P4HA2 Proteine) are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (zeige TNF Proteine)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS (zeige TLR4 Proteine) via annexin A1 (zeige ANXA1 Proteine).
findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS (zeige MAS1 Proteine)) and a potential novel therapeutic target for MAS (zeige MAS1 Proteine).
Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.
Plasminogen may regulate DPP-4 (zeige DPP4 Proteine) activity and glucose metabolism.
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (zeige SLC11A2 Proteine) C (zeige PROC Proteine) (MntC) is an extracellular matrix- and plasminogen-binding protein (zeige ENO1 Proteine)
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (zeige Lp-PLA2 Proteine)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
plg-/- and tPA (zeige PLAT Proteine)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B