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Human MASP1 ELISA Kit für Sandwich ELISA - ABIN415090
Radu, Hu, Jiang, Bok: Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype. in The Journal of biological chemistry 2014
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MBL (zeige MBL2 ELISA Kits)-KO (Figure 1a) and MASP-1-KO (Figure 1b) mice are poor mobilizers in response to mobilizing agents compared with WT littermates
this study shows that inhibition of MASP-1/3 by gene silencing is sufficient to ameliorate collagen Ab-induced arthritis in mice
MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice
study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis.
Data indicate that co-deficiency of factor H (FH (zeige CFH ELISA Kits)) and MASP-1/MASP-3 did not ameliorate either the plasma Complement C3 (zeige C3 ELISA Kits) (C3) activation or glomerular C3 accumulation in FH-deficient mice.
Within the mannose-binding lectin (zeige MBL2 ELISA Kits)/MASP complex, MASP-1 is the necessary complement component for thrombin (zeige F2 ELISA Kits)-like activity in vitro.
We conclude that MASP-1 does not require binding to mannose binding lectins or ficolins to activate the alternative pathway of complement
we investigated the mechanism of MASP-3 activation and its substrate using the recombinant mouse MASP-3 (rMASP-3) and several different types of MASP-deficient mice
Our studies demonstrate for the first time, to our knowledge, the absolute requirement for the activity of MASP-1 protein in autoimmune-associated inflammatory tissue injury
MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.
Our finding suggests that complement MASP-1 can increase adhesion between neutrophils and endothelial cells in a direct fashion
Study discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1 (zeige THBS1 ELISA Kits), GPLD1 (zeige GPLD1 ELISA Kits) and ApoA-IV (zeige APOA4 ELISA Kits), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.
MASP-1 was not associated with adverse cardiovascular outcomes in diabetics.
high serum CL-L1 (zeige COLEC10 ELISA Kits) concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration
The exclusion of the MASP1 and COLEC11 (zeige COLEC11 ELISA Kits) Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome
Plasma MASP-1 concentration at the early stage of Kawasaki disease is predictive of length of time of recovery from coronary artery lesions.
MASP-1 and MASP-2 (zeige MASP2 ELISA Kits) are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.
described for the first time a detailed model of prothrombin (zeige F2 ELISA Kits) activation by MASP-1
Fusion of MAP-1 with FH domains represents a novel therapeutic approach for selective targeting upstream and central complement activation at sites of inflammation
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
, complement factor MASP-3
, complement-activating component of Ra-reactive factor
, mannan-binding lectin serine protease 1
, mannose-binding lectin-associated serine protease 1
, mannose-binding protein-associated serine protease
, ra-reactive factor serine protease p100
, serine protease 5
, Ra-reactive factor serine protease p100