anti-Human MASP1 Antikörper für Immunoassay

Recommended MASP1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Antikörper
  • AW048060
  • CCPII
  • Crarf
  • Masp1/3
  • 3MC1
  • CRARF
  • CRARF1
  • MAP1
  • MASP
  • MASP3
  • MAp44
  • PRSS5
  • RaRF
  • mannan-binding lectin serine peptidase 1
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
  • Masp1
  • MASP1
Reaktivität
Human
74
24
24
2
2
1
1
1
1
Wirt
Maus
53
20
1
Klonalität
Monoklonal
Konjugat
Dieser MASP1 Antikörper ist unkonjugiert
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunoassay (IA), Immunoprecipitation (IP), Western Blotting (WB)
60
19
13
5
3
3
3
1
1
Optionen
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Produktnummer ABIN2191968
491,43 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2191969 IA IP WB Mouse Anmelden zum Anzeigen 2B11 6

anti-MASP1 Antikörper für Immunoassay mit den meisten Publikationen

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Applikation / Reaktivität Human
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General

Antigen Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Antikörper
Reaktivität Human
(74), (24), (24), (2), (2), (1), (1), (1), (1)
Wirt Maus
(53), (20), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser MASP1 Antikörper ist unkonjugiert
(4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunoassay (IA), Immunoprecipitation (IP), Western Blotting (WB)
(60), (19), (13), (5), (3), (3), (3), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-MASP1 Antikörper

Target Details MASP1 Anwendungsinformationen Handhabung ProductDetails: References for anti-MASP1 antibody (ABIN2191968) Bilder
Sterilität 0.2 μm filtered
Klon 1E2

Target Details MASP1

Produktdetails anti-MASP1 Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-MASP1 antibody (ABIN2191968) Bilder zurück nach oben
Antigen
Andere Bezeichnung Masp-1/3 (MASP1 Antibody Abstract)
Hintergrund Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP- 1, MASP-2 and MASP-3. MASP-1 appears to cleave the second complement component C2, but not C4. The proteolytic activities of MASP-1 are inhibited by C1-inhibitor. Furthermore MASP-1 has a reactivity profile very similar to that of thrombin. MASP-1 is able to catalyse the formation of cross-linked fibrin. Participation of MASP-1 in cross- linked fibrin clot formation causes release of a chemotactic factor representing a biologically significant activity of MASP-1. The alternative-splicing product from MASP-1 gene is called MASP-3. MASP-1 is associated with smaller MBL oligomers whereas MASP-3 is found on larger oligomers. The substrate of MASP-3 is unknown. The antibody recognizes the heavy chain common to both MASP-1 and MASP-3.
Pathways Komplementsystem

Anwendungsinformationen

Produktdetails anti-MASP1 Antikörper Target Details MASP1 Handhabung ProductDetails: References for anti-MASP1 antibody (ABIN2191968) Bilder zurück nach oben
Applikationshinweise For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. The antibody does not work in Western blotting of reduced samples.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-MASP1 Antikörper Target Details MASP1 Anwendungsinformationen ProductDetails: References for anti-MASP1 antibody (ABIN2191968) Bilder zurück nach oben
Buffer PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Haltbarkeit 12 months

ProductDetails: References for anti-MASP1 antibody (ABIN2191968)

Produktdetails anti-MASP1 Antikörper Target Details MASP1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Hajela, Kojima, Ambrus, Wong, Moffatt, Ferluga, Hajela, Gál, Sim: "The biological functions of MBL-associated serine proteases (MASPs)." in: Immunobiology, Vol. 205, Issue 4-5, pp. 467-75, 2002

Endo, Takahashi, Kuraya, Matsushita, Stover, Schwaeble, Fujita: "Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter." in: International immunology, Vol. 14, Issue 10, pp. 1193-201, 2002

Kuraya, Matsushita, Endo, Thiel, Fujita: "Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G." in: International immunology, Vol. 15, Issue 1, pp. 109-17, 2002

Matsushita, Kuraya, Hamasaki, Tsujimura, Shiraki, Fujita: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, 2002

Matsushita, Endo, Hamasaki, Fujita: "Activation of the lectin complement pathway by ficolins." in: International immunopharmacology, Vol. 1, Issue 3, pp. 359-63, 2001