anti-Human FCN3 Antikörper für Enzyme Immunoassay

Recommended FCN3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) Antikörper
  • FCNH
  • HAKA1
  • ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
  • FCN3
Epitop
AA 213-243, C-Term
14
9
6
5
5
4
3
1
1
Reaktivität
Human
44
2
1
1
1
1
1
1
1
1
1
1
1
Wirt
Kaninchen
37
7
Klonalität
Polyklonal
Konjugat
Dieser FCN3 Antikörper ist unkonjugiert
4
3
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
40
28
17
17
3
3
1
1
Hersteller
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Bilder

Produktnummer ABIN952329
$ 390.50
Zzgl. Versandkosten $45.00

General

Antigen Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) Antikörper
Epitop AA 213-243, C-Term
(14), (9), (6), (5), (5), (4), (3), (1), (1)
Reaktivität Human
(44), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Wirt Kaninchen
(37), (7)
Klonalität
Polyklonal
Konjugat Dieser FCN3 Antikörper ist unkonjugiert
(4), (3), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(40), (28), (17), (17), (3), (3), (1), (1)
Pubmed 5 Publikationen vorhanden
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Produktdetails anti-FCN3 Antikörper

Target Details FCN3 Anwendungsinformationen Handhabung Referenzen für anti-FCN3 Antikörper (ABIN952329) Bilder
Spezifität This antibody reacts to FCN3.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 213-243 amino acids from the C-terminal region of human FCN3
Isotyp Ig

Target Details FCN3

Produktdetails anti-FCN3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-FCN3 Antikörper (ABIN952329) Bilder zurück nach oben
Antigen
Andere Bezeichnung Ficolin-3 (FCN3 Antibody Abstract)
Hintergrund Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.Synonyms: Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, FCN3, FCNH, Ficolin3, HAKA1, Hakata antigen
Molekulargewicht 32903 Da
Gen-ID 8547
NCBI Accession NP_003656
Pathways Komplementsystem

Anwendungsinformationen

Produktdetails anti-FCN3 Antikörper Target Details FCN3 Handhabung Referenzen für anti-FCN3 Antikörper (ABIN952329) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-FCN3 Antikörper Target Details FCN3 Anwendungsinformationen Referenzen für anti-FCN3 Antikörper (ABIN952329) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-FCN3 Antikörper (ABIN952329)

Produktdetails anti-FCN3 Antikörper Target Details FCN3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010

Andersen, Munthe-Fog, Garred, Jacobsen: "Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus." in: The Journal of rheumatology, Vol. 36, Issue 4, pp. 757-9, 2009

Ruskamp, Hoekstra, Postma, Kerkhof, Bottema, Koppelman, Rovers, Wijga, de Jongste, Brunekreef, Sanders: "Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children." in: Clinical and experimental immunology, Vol. 155, Issue 3, pp. 433-40, 2009

Lacroix, Dumestre-Pérard, Schoehn, Houen, Cesbron, Arlaud, Thielens: "Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 456-65, 2008

Munthe-Fog, Hummelshøj, Ma, Hansen, Koch, Madsen, Skjødt, Garred: "Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state." in: Molecular immunology, Vol. 45, Issue 9, pp. 2660-6, 2008

Bilder

Produktdetails anti-FCN3 Antikörper Target Details FCN3 Anwendungsinformationen Handhabung Referenzen für anti-FCN3 Antikörper (ABIN952329) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 213-243), (C-Term) antibody (ABIN952329) FCN3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin e...
Western Blotting (WB) image for anti-Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (AA 213-243), (C-Term) antibody (ABIN952329) FCN3 Antibody (C-term) western blot analysis in K562 cell line lysates (35µg/lane).Th...