anti-Human Complement Component 5 Antikörper für ELISA (Detection)

Recommended Complement Component 5 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Complement Component 5 (C5) Antikörper
  • C5
  • LOC565774
  • C5a
  • C5b
  • CPAMD4
  • Hc
  • RGD1561905
  • He
  • complement component 5
  • similar to complement component C5-1
  • hemolytic complement
  • C5
  • LOC565774
  • Hc
Reaktivität
Human
144
22
10
7
2
2
2
1
Wirt
Maus
85
75
11
6
Klonalität
Monoklonal
Konjugat
Unkonjugiert
14
12
6
6
5
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA (Detection), Functional Studies (Func), Western Blotting (WB)
103
82
28
22
18
16
13
10
10
9
8
7
6
5
4
3
2
2
2
1
1
1
1
1
Hersteller
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Produktnummer ABIN1106793
385,00 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1106795 ELISA (Detection) Func Mouse IgG2a N-Term Anmelden zum Anzeigen 561 1

anti-Complement Component 5 Antikörper für ELISA (Detection) mit den meisten Publikationen

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General

Antigen Complement Component 5 (C5) Antikörper
Reaktivität Human
(144), (22), (10), (7), (2), (2), (2), (1)
Wirt Maus
(85), (75), (11), (6)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Unkonjugiert
(14), (12), (6), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA (Detection), Functional Studies (Func), Western Blotting (WB)
(103), (82), (28), (22), (18), (16), (13), (10), (10), (9), (8), (7), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Kreuzreaktivität (Details) Species reactivity (tested):Human
Reinigung Protein G
Immunogen Human C5
Klon 557
Isotyp IgG2a

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung Complement C5 (C5 Antibody Abstract)
Hintergrund The complement system is composed of over 30 proteins, activated in response to tissue injury, invading pathogens or other foreign surfaces. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a was first described as a cleavage product of C5 with chemotactic and anaphylatoxic properties. Further characterization revealed that C5a is an essential part of the innate immune response and evidence now suggests that it may also play a role in adaptive immunity. Complement fragment C5a is a 74 residue pro-inflammatory polypeptide. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase pathways, thereby by inducing synthesis of cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8. Its in vivo blockade greatly reduces inflammatory injury. Much less is known about C5L2, occupancy of which by C5a does not initiate increased intracellular Ca(2+).The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases. Nowadays C5a is also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and haematopoiesis.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4, Complement component 5
Gen-ID 9606
UniProt P01031
Forschungsgebiet Complement Factors
Pathways Komplementsystem, Carbohydrate Homeostasis

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Kola, Baensch, Bautsch, Klos, Köhl: "Analysis of the C5a anaphylatoxin core domain using a C5a phage library selected on differentiated U937 cells." in: Molecular immunology, Vol. 36, Issue 2, pp. 145-52, 1999