Leptin Proteine (LEP)

Bezeichnung:
Leptin Proteine (LEP)
Auf www.antikoerper-online.de finden Sie aktuell 205 Leptin (LEP) Proteine von 21 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Leptin Antikörper (607) und Leptin Kits (200) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1049 Leptin Produkte verfügbar.
Synonyme:
LEPD, OB, obese, OBS
alle Proteine anzeigen Gen GeneID UniProt
LEP 16846 P41160
LEP 3952 P41159
LEP 25608 P50596

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Am meisten referenzierte Leptin Proteine

  1. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN1047336 : Zhang, Proenca, Maffei, Barone, Leopold, Friedman: Positional cloning of the mouse obese gene and its human homologue. in Nature 1994 (PubMed)
    Zeige alle 4 Referenzen für 1047336

  2. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917 : Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011 (PubMed)
    Zeige alle 3 Referenzen für 803917

  3. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN666843 : Anini, Brubaker: Role of leptin in the regulation of glucagon-like peptide-1 secretion. in Diabetes 2003 (PubMed)
    Zeige alle 3 Referenzen für 666843

  4. Mouse (Murine) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN667698 : Hyogo, Roy, Paigen, Cohen: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 3 Referenzen für 667698

  5. Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914 : Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006 (PubMed)

Weitere Proteine zu Leptin Interaktionspartnern

Mouse (Murine) Leptin (LEP) Interaktionspartner

  1. leptin is involved in the proliferation and activation of microglia, which in turn enhances the development of neuropathic pain after avulsion of the cervical roots.

  2. Suggest that intact endothelial leptin signaling limits neointima formation and that obesity represents a state of endothelial leptin resistance.

  3. these studies demonstrate marked differences in the acute insulin (zeige INS Proteine)-independent effects by which leptin reverses fasting hyperglycemia and ketoacidosis in a rodent model of DKA versus the chronic pleotropic effects by which leptin reverses hyperglycemia in a non-DKA rodent model of T1D.

  4. High fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most (but not all) brain regions, while other brain regions display hypersensitivity to leptin following weight loss

  5. CNS-specific Tak1 (zeige NR2C2 Proteine) deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 (zeige NR2C2 Proteine) is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.

  6. These data further implicate IL-6 (zeige IL6 Proteine) in fatty liver disease modulation in the context of DIO, and indicate that continuous stimulation with IL-6 (zeige IL6 Proteine) attenuates the IL-6 (zeige IL6 Proteine)-receptor response, which is associated with high serum levels of leptin.

  7. these data unmasked a role for mitochondrial fission in leptin sensitivity and glucose sensing of POMC (zeige POMC Proteine) neurons.

  8. Obesity and leptin deficiency substantially decreased morphine metabolism and clearance.

  9. These findings suggest that by impairing the testicular LEP-JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) pathway, early-stage obesity inhibits the biosynthesis of testosterone and sexual development and reduces male reproductive potential. Long-term moderate and high-volume exercise can effectively reduce body fat and improve obesity-induced abnormalities in testicular leptin signal transduction, whereas only moderate-volume exercise can reverse the negativ

  10. genetic and pharmacological ablation of adult NG2 (zeige Vcan Proteine)-glia (also known as oligodendrocyte precursors), but not microglia, leads to primary leptin resistance and obesity in mice.

Human Leptin (LEP) Interaktionspartner

  1. Serum leptin levels were associated in patients with stable angina with the severity of coronary artery disease, suggesting its value in the development of coronary disease and as a future therapeutic target.

  2. In a sample selected for severe early onset childhood obesity, no leptin gene mutations leading to decreased proportion of bioactive leptin were identified.

  3. Maternal pre-pregnancy BMI is strongly associated with decreased cord blood LEP gene methylation and may mediate the well-known association between maternal pre-pregnancy BMI and neonatal adiposity

  4. hot flash association with insulin (zeige INS Proteine) resistance is dependent on the combination of leptin and adiponectin (zeige ADIPOQ Proteine) variables

  5. There was a strong relationship between growth hormone receptor (GHR (zeige GHR Proteine))-d3/fl gene polymorphism status and leptin levels in acromegalic patients

  6. in human colon cancer, upregulation of leptin pathway members was shown with a large network of dysregulated transcripts being linked with worse overall survival.

  7. In European children, higher leptin concentration is associated with metabolic syndrome, even after adjusting for BMI or body fat mass, confirming an early role of leptin in MetS.

  8. Leptin, at concentrations with minimal or no activating effects on astrocytoma cells, enhanced growth and migration promoted by low doses of sPLA2-IIA (zeige PLA2G2A Proteine). sPLA2-IIA (zeige PLA2G2A Proteine) alone induced a transient phosphorylation pattern in the Src (zeige SRC Proteine)/ERK (zeige EPHB2 Proteine)/Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine)/p70S6K (zeige RPS6KB1 Proteine)/rS6 pathway through EGFR (zeige EGFR Proteine) transactivation

  9. a novel mechanism by which compromised HDLECs maintain their homeostasis during inflammation mediated by leptin and IL-6 (zeige IL6 Proteine)

  10. In this study of a predominantly minority population, no association between premorbid leptin levels and cancer incidence was demonstrated

Pig (Porcine) Leptin (LEP) Interaktionspartner

  1. The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.

  2. A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.

  3. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  4. Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.

  5. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  6. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  7. Another funning discovery is ob-Rb (zeige LEPR Proteine) mRNA in porcine endometrium was mainly negative-regulated by leptin

  8. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance

  9. Leptin and leptin receptor (zeige LEPR Proteine) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

  10. The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.

Cow (Bovine) Leptin (LEP) Interaktionspartner

  1. Consistent with this, leptin enhanced GnRH (zeige GNRH1 Proteine)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (zeige CA2 Proteine)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.

  2. The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.

  3. A leptin SNP (LEPg.978) was significantly associated with a weight at one year.

  4. The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.

  5. Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.

  6. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (zeige NPY Proteine) and insulin (zeige INS Proteine) signaling pathways.

  7. Leptin R25C genotype impacted most traits associated with fatness.

  8. The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.

  9. Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (zeige NPY Proteine)) release.

  10. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

Goat Leptin (LEP) Interaktionspartner

  1. polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production

Rabbit Leptin (LEP) Interaktionspartner

  1. study suggests that increased CSF (zeige CSF2 Proteine) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (zeige IGF1 Proteine) after traumatic brain injury, leads to accelerated fracture healing

  2. We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (zeige GHRL Proteine).

  3. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.

Horse (Equine) Leptin (LEP) Interaktionspartner

  1. Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.

  2. Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.

  3. Plasma levels of leptin (as well as glucose, insulin (zeige INS PLURAL_@44953@), and growth hormone (zeige GH1 PLURAL_@44953@)) are highly correlated with the duration of winter anovulatory phase.

  4. GHRL (zeige GHRL Proteine), LEP, ADIP (zeige SSX2IP Proteine), INS (zeige INS Proteine) and CORT (zeige CORT Proteine) concentrations were measured using radioimmunoassay

  5. positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares

Rhesus Monkey Leptin (LEP) Interaktionspartner

  1. The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (zeige ADIPOQ Proteine), leptin, and resistin (zeige RETN Proteine) in a set of four chair-restraint habituated intact adult male rhesus monkeys.

  2. results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction

Leptin (LEP) Protein Überblick

Protein Überblick

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Alternative names and synonyms associated with Leptin (LEP)

  • leptin (Lep)
  • leptin (LEP)
  • leptin (lep)
  • LEPD Protein
  • OB Protein
  • obese Protein
  • OBS Protein

Bezeichner auf Proteinebene für Leptin Proteine (LEP)

obesity factor , leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , obese protein , obese, mouse, homolog of , obese

GENE ID SPEZIES
16846 Mus musculus
3952 Homo sapiens
25608 Rattus norvegicus
443534 Ovis aries
396832 Sus scrofa
280836 Bos taurus
100860794 Capra hircus
100008747 Oryctolagus cuniculus
373955 Gallus gallus
403616 Canis lupus familiaris
100034042 Equus caballus
493838 Felis catus
449638 Pan troglodytes
100716751 Cavia porcellus
698728 Macaca mulatta
548631 Takifugu rubripes
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