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We found that quercetin reduces the promoter activity of apoB (zeige APOB ELISA Kits), driven by the enforced expression of C/EBPb.
Chromatin immunoprecipitation analysis revealed that C/EBPbeta2 binds to multiple sites at the 5' promoter/regulatory region, introns, and the 3' untranslated region of the IGF-II gene.
C/EBPbeta negatively regulates PR-B (zeige PGR ELISA Kits) expression in glioblastoma cells.
High CEBPB expression is associated with recurrence in Glioma.
Study results show the role of WT1 (zeige WT1 ELISA Kits) in regulating decidualization in human endometrial stromal cells. C/EBPbeta is an upstream gene that regulates WT1 (zeige WT1 ELISA Kits) expression by binding to the novel enhancer region.
EGFR (zeige EGFR ELISA Kits) and C/EBP-beta oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta isoform
Studied expression of CD147 in both ALK (zeige ALK ELISA Kits)+ and ALK (zeige ALK ELISA Kits)- anaplastic large-cell lymphoma; found CD147 to be a downstream target for activation by C/EBPbeta.
Data show that in an in vitro acute lung injury model established by lipopolysaccharide induction, phosphorylation of C/EBP beta was decreased and bioinformatics analysis discovered a putative binding site of C/EBP beta in CCSP1 (zeige KIAA1199 ELISA Kits) promoter; LPS (zeige IRF6 ELISA Kits) stimulation reduced C/EBP beta phosphorylation and suppressed the transcription of CCSP1 (zeige KIAA1199 ELISA Kits).
Increased polyamine metabolism in CRC (zeige CALR ELISA Kits) could be driven by c-Myc (zeige MYC ELISA Kits) and C/EBPbeta rather than Bacteroides fragilis infection.
SBDS (zeige SBDS ELISA Kits) function is specifically required for efficient translation re-initiation into the protein isoforms C/EBPalpha (zeige CEBPA ELISA Kits)-p30 (zeige CENPV ELISA Kits) and C/EBPbeta-LIP, which is controlled by a single cis (zeige CISH ELISA Kits)-regulatory upstream open reading frame (uORF) in the 5' untranslated regions (5' UTRs) of both mRNAs.
A transcription factor complex consisting of ATF6 (zeige ATF6 ELISA Kits) (an endoplasmic reticulum-resident factor) and C/EBP-beta is required for the IFN-gamma-induced (zeige SAMHD1 ELISA Kits) expression of DAPK1 (zeige DAPK1 ELISA Kits) IFN-gamma-induced (zeige SAMHD1 ELISA Kits) proteolytic processing of ATF6 (zeige ATF6 ELISA Kits) and phosphorylation of C/EBP-beta are obligatory for the formation of this transcriptional complex
Data show that CCAAT/enhancer-binding protein beta (C/EBP beta) expression is increased in endothelial cells and retinal pigment epithelial cells infected by Toxoplasma gondii, resulting in the activation of autophagy in host cells by inhibiting mechanistic target of rapamycin (zeige FRAP1 ELISA Kits) protein (mTOR (zeige FRAP1 ELISA Kits)) pathway.
elevated LIP/LAP ratio robustly increased Ogn (zeige OGN ELISA Kits) expression and cell death under stress by modulating the mitogen-activated protein kinase (zeige MAPK1 ELISA Kits)/activator protein 1 (zeige JUN ELISA Kits) pathway (MAPK (zeige MAPK1 ELISA Kits)/AP-1 (zeige JUN ELISA Kits)).
Ptn (zeige PTN ELISA Kits) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP (zeige TMPRSS5 ELISA Kits)-Hand2 (zeige HAND2 ELISA Kits) signaling.
C/EBPbeta is a critical factor for Ly6C(-) monocyte survival, at least in part through upregulation of Csf1r (zeige CSF1R ELISA Kits).
these results support that decreasing C/EBPbeta expression prevents MDSC generation and decreases immunosuppression in septic mice, providing a target for sepsis treatment.
Functional characterization of C/EBPa (zeige CEBPA ELISA Kits) and C/EBPb proteomes suggests they can regulate novel pathways.
PARP-1 (zeige PARP1 ELISA Kits) attenuates adipogenesis by PARylating C/EBPb, a pro-adipogenic transcription factor, on three residues in its regulatory domain.
Results show that C/EBPbeta and C/EBPdelta (zeige CEBPD ELISA Kits) actively regulate the promotor region of both splicing variants Ppargamma1sv and Ppargamma2 (zeige PPARG ELISA Kits) in mouse adipocytes.
These results show that C/EBPbeta directs a switch from proinflammatory to repressor myeloid cells
Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16 (zeige PRDM16 ELISA Kits)) to determine brown/beige (zeige LYST ELISA Kits) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (zeige SLC39A13 ELISA Kits)
monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBPbeta and C/EBPbeta-deficient mice lacked Ly6C(-) monocytes.
C/EBP-beta plays a vital role in regulating GPR120 (zeige O3FAR1 ELISA Kits) transcription.
The expression of porcine Prdx6 (zeige PRDX6 ELISA Kits) gene is up-regulated by C/EBPbeta and CREB (zeige CREB1 ELISA Kits).
Results show that expression changes of IGF1 (zeige IGF1 ELISA Kits) genes were associated with C/EBP (zeige CEBPA ELISA Kits) b expression during embryonic and postnatal development in porcine liver.
FoxO1 (zeige FOXO1 ELISA Kits) and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1 (zeige FOXO1 ELISA Kits)-> C/EBPb feedback regulatory loop and FoxO1 (zeige FOXO1 ELISA Kits)-C/EBPb protein complex.
the pig GPD1 (zeige GPD1 ELISA Kits) gene is regulated negatively by C/EBP beta in cultured kidney cells
GATA-4 (zeige GATA4 ELISA Kits) and C/EBPbeta are both required for FSH (zeige BRD2 ELISA Kits) +/- IGF-I (zeige IGF1 ELISA Kits) stimulation of the porcine steroidogenic acute regulatory protein (zeige STAR ELISA Kits) gene promoter in homologous granulosa cell cultures.
The differential expression of specific CEBPA (zeige CEBPA ELISA Kits)/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
SREBP1a activated while C/EBP (zeige CEBPA ELISA Kits) factors downregulated the activity of the SCD1 (zeige SCD ELISA Kits) promoter.
These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related (zeige SYCE2 ELISA Kits) genes expression and function of bovine SCs (zeige TWIST1 ELISA Kits).
Suppression of CPT1B (zeige CPT1B ELISA Kits) and induction of SCD (zeige SCD ELISA Kits) and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma (zeige PPARG ELISA Kits) gene expression in differentiated myoblasts and an increase in GPR43 (zeige FFAR2 ELISA Kits) gene expression in adipocytes.
Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha (zeige ACACA ELISA Kits) gene in cattle.
The role of NF-kappaB (zeige NFKB1 ELISA Kits) and C/EBP (zeige CEBPA ELISA Kits) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
The 3' terminal end of the first intron of porcine SPP1 (zeige SPP1 ELISA Kits) harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
CCAAT/enhancer binding protein (C/EBP), beta
, CCAAT/enhancer-binding beta protein b
, CCAAT/enhancer-binding protein beta
, CCAAT/enhancer binding protein beta
, interleukin 6-dependent DNA-binding protein
, liver-enriched transcriptional activator protein
, nuclear factor NF-IL6
, nuclear factor of interleukin 6
, transcription factor 5
, C/EBP BETA
, interleukin-6-dependent-binding protein
, liver-enriched transcriptional activator
, nuclear protein Il6
, C/EBP beta
, c/EBP-related protein 2
, liver activating protein (LAP)
, nuclear factor-IL6
, silencer factor B
, c/EBP beta
, CCAAT box/enhancer binding protein beta
, CCR protein
, transcription factor NF-M