Integrin alpha 4 Proteine (ITGA4)

Auf www.antikoerper-online.de finden Sie aktuell 8 Integrin alpha 4 (ITGA4) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Integrin alpha 4 Antikörper (692) und Integrin alpha 4 Kits (16) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 725 Integrin alpha 4 Produkte verfügbar.
Synonyme:
CD49D, IA4, LOC100219853
alle Proteine anzeigen Gen GeneID UniProt
ITGA4 3676 P13612
ITGA4 16401 Q00651
Ratte ITGA4 ITGA4 311144  

Integrin alpha 4 Proteine (ITGA4) nach Spezies

Weitere Proteine zu Integrin alpha 4 Interaktionspartnern

Human Integrin alpha 4 (ITGA4) Interaktionspartner

  1. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  2. sPLA2-IIA (zeige PLA2G2A Proteine) activates Integrin alphaVbeta3 (zeige ITGAV Proteine) and Integrin alpha4beta1 in an allosteric manner. (Review)

  3. Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID (zeige TNFRSF13B Proteine) patients

  4. In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C (zeige VEGFC Proteine). Integrin alpha4 and VEGF-C (zeige VEGFC Proteine) were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C (zeige VEGFC Proteine) expression had significantly shorter overall survival and tumor-free survival time.

  5. Macrophage tissue factor (zeige F3 Proteine) prothrombotic activity is regulated by integrin-alpha4/arf6 (zeige ARF6 Proteine) trafficking.

  6. gut (zeige GUSB Proteine)-homing alpha4beta7 CD4 (zeige CD4 Proteine)(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.

  7. Data show tht Rho kinase (zeige ROCK1 Proteine) (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia.

  8. These data showed that Mycobacterium tuberculosis ESAT-6 and ESAT-6/CFP (zeige CFP Proteine)-10 fusion proteins could induce adhesion of macrophages to fibronectin (zeige FN1 Proteine) through alpha4beta1 integrin.

  9. Enhanced susceptibility of activated endocervical CD4+ T cells to HIV may be related to increased CCR5 expression by these cell subsets, but did not appear to be due to direct interaction of integrins a4b7 or a4b1 with HIV envelope.

  10. knockdown of PTTG1 (zeige PTTG1 Proteine) increased expression of integrin alpha 4 (ITGA4), ITGA5 (zeige ITGA5 Proteine), and integrin beta 1 (ITGB1 (zeige ITGB1 Proteine)); otherwise, RhoA (zeige RHOA Proteine) expression was significantly decreased

Mouse (Murine) Integrin alpha 4 (ITGA4) Interaktionspartner

  1. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  2. Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1 (zeige VCAM1 Proteine), respectively; expression of the latter was upregulated in obesity.

  3. uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology

  4. Macrophage tissue factor (zeige F3 Proteine) prothrombotic activity is regulated by integrin-alpha4/arf6 (zeige ARF6 Proteine) trafficking.

  5. this study shows that alpha4beta1 integrin mediates memory CD8 (zeige CD8A Proteine)+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus

  6. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 (zeige MADCAM1 Proteine) interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  7. These results suggest that Tie2 (zeige TEK Proteine) signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (zeige VCAM1 Proteine).

  8. ITGA4 expression enhances metastasis in MYCN (zeige MYCN Proteine) low neuroblastoma (zeige ARHGEF16 Proteine).

  9. CD49d-high-expressing Th1 (zeige HAND1 Proteine) memory phenotype CD4 (zeige CD4 Proteine)+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.

  10. Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1 (zeige VCAM1 Proteine)) axis.

Rhesus Monkey Integrin alpha 4 (ITGA4) Interaktionspartner

  1. Administration of a novel recombinant antibody against alpha4beta7 gut (zeige GUSB Proteine)-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut (zeige GUSB Proteine) tissues from acute lentiviral infection.

Integrin alpha 4 (ITGA4) Protein Überblick

Protein Überblick

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

Alternative names and synonyms associated with Integrin alpha 4 (ITGA4)

  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)
  • integrin alpha 4 (Itga4)
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (LOC100219853)
  • integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (itga4)
  • integrin, alpha 4 (Itga4)
  • CD49D Protein
  • IA4 Protein
  • LOC100219853 Protein

Bezeichner auf Proteinebene für Integrin alpha 4 Proteine (ITGA4)

269C wild type , CD49 antigen-like family member D , VLA-4 subunit alpha , antigen CD49D, alpha-4 subunit of VLA-4 receptor , integrin alpha 4 , integrin alpha-4 , integrin alpha-4 subunit , integrin alpha-IV , very late activation protein 4 receptor, alpha 4 subunit , LPAM subunit alpha , VLA-4 receptor, alpha 4 subunit , lymphocyte Peyer patch adhesion molecules subunit alpha

GENE ID SPEZIES
3676 Homo sapiens
16401 Mus musculus
100219853 Taeniopygia guttata
397839 Xenopus laevis
470596 Pan troglodytes
704745 Macaca mulatta
311144 Rattus norvegicus
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