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Mouse (Murine) Integrin beta 4 ELISA Kit für Sandwich ELISA - ABIN816650
Wu, Zhou, Duan, Wang, Xiao, Duan, Li, Li, Wan, Liu, Song, Zhou, Huang, Wang: Reconstruction of auto-tissue-engineered lamellar cornea by dynamic culture for transplantation: a rabbit model. in PLoS ONE 2014
Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl (zeige ABL1 ELISA Kits) transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl (zeige ABL1 ELISA Kits) kinases and p73 (zeige ARHGAP24 ELISA Kits) protein pathway(s).
Integrin beta4 contributes to mammary gland development by sustaining PTHrP (zeige PTHLH ELISA Kits) expression and enabling PTHrP (zeige PTHLH ELISA Kits) signaling.
keratins have a role in controlling beta4-integrin endocytosis involving a plectin (zeige PLEC ELISA Kits)-Erk1/2 (zeige MAPK1/3 ELISA Kits)-dependent mechanism relevant for epidermal differentiation and pathogenesis
Up-regulation of integrin beta4 and TRPV1 (zeige TRPV1 ELISA Kits) in migrating keratinocytes.
Ectopic induction of Nur77 (zeige NR4A1 ELISA Kits) in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 (zeige NR4A1 ELISA Kits) regulates the expression of integrin beta4 by targeting its promoter activity.
Col17a1 (zeige COL17A1 ELISA Kits)/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.
Both annexin A7 (zeige ANXA7 ELISA Kits) and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.
Findings indicate a function for Id2 in regulating Snai1 (zeige SNAI1 ELISA Kits)-mediated repression of integrin beta4.
Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 (zeige TP53 ELISA Kits) and Rb function in a model of prostate cancer (PB-TAg mice).
Deficiency of integrin alpha(6 (zeige ITGA6 ELISA Kits))beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (zeige IGF1R ELISA Kits).
MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK (zeige PTK2 ELISA Kits) at Y397 leading to lung cancer cell migration.
a significant reduction in the protein distribution of collagen IV (zeige COL4 ELISA Kits) (P<0.0001), collagen VII (zeige TH ELISA Kits) (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.
For the in vivo experiment, miR (zeige MLXIP ELISA Kits)-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR (zeige MLXIP ELISA Kits)-182-5p may be a key androgen receptor (zeige AR ELISA Kits)-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
data indicate that the beta4 integrin/FAK (zeige PTK2 ELISA Kits) complex and subsequent FAK (zeige PTK2 ELISA Kits) activation are essential regulators during the tumorigenicity of colon cancer
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]
ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (zeige FAM126A ELISA Kits) by conferring anchorage independence through EGFR (zeige EGFR ELISA Kits)-dependent FAK (zeige PTK2 ELISA Kits)-AKT (zeige AKT1 ELISA Kits) activation.
High vimentin and low beta4 integrin protein levels are associated with poor survival in oral squamous carcinoma patients.
Endothelial cell overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
integrin beta 4
, integrin beta-4
, CD104 antigen
, integrin beta-4 subunit